Elevated Expression of Fractalkine (CX3CL1) and Fractalkine Receptor (CX3CR1) in the Dorsal Root Ganglia and Spinal Cord in Experimental Autoimmune Encephalomyelitis: Implications in Multiple Sclerosis-Induced Neuropathic Pain

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dc.contributor.authorZhu, Wenjun
dc.contributor.authorAcosta, Crystal
dc.contributor.authorMacNeil, Brian
dc.contributor.authorCortes, Claudia
dc.contributor.authorIntrater, Howard
dc.contributor.authorGong, Yuewen
dc.contributor.authorNamaka, Mike
dc.date.accessioned2014-08-14T06:46:43Z
dc.date.available2014-08-14T06:46:43Z
dc.date.issued2013-9-24
dc.date.updated2014-08-14T06:46:43Z
dc.description.abstractMultiple sclerosis (MS) is a central nervous system (CNS) disease resulting from a targeted autoimmune-mediated attack on myelin proteins in the CNS. The release of Th1 inflammatory mediators in the CNS activates macrophages, antibodies, and microglia resulting in myelin damage and the induction of neuropathic pain (NPP). Molecular signaling through fractalkine (CX3CL1), a nociceptive chemokine, via its receptor (CX3CR1) is thought to be associated with MS-induced NPP. An experimental autoimmune encephalomyelitis (EAE) model of MS was utilized to assess time dependent gene and protein expression changes of CX3CL1 and CX3CR1. Results revealed significant increases in mRNA and the protein expression of CX3CL1 and CX3CR1 in the dorsal root ganglia (DRG) and spinal cord (SC) 12 days after EAE induction compared to controls. This increased expression correlated with behavioural thermal sensory abnormalities consistent with NPP. Furthermore, this increased expression correlated with the peak neurological disability caused by EAE induction. This is the first study to identify CX3CL1 signaling through CX3CR1 via the DRG /SC anatomical connection that represents a critical pathway involved in NPP induction in an EAE model of MS.
dc.description.versionPeer Reviewed
dc.identifier.citationWenjun Zhu, Crystal Acosta, Brian MacNeil, et al., “Elevated Expression of Fractalkine (CX3CL1) and Fractalkine Receptor (CX3CR1) in the Dorsal Root Ganglia and Spinal Cord in Experimental Autoimmune Encephalomyelitis: Implications in Multiple Sclerosis-Induced Neuropathic Pain,” BioMed Research International, vol. 2013, Article ID 480702, 14 pages, 2013. doi:10.1155/2013/480702
dc.identifier.doihttp://dx.doi.org/10.1155/2013/480702
dc.identifier.urihttp://hdl.handle.net/1993/23767
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2013 Wenjun Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleElevated Expression of Fractalkine (CX3CL1) and Fractalkine Receptor (CX3CR1) in the Dorsal Root Ganglia and Spinal Cord in Experimental Autoimmune Encephalomyelitis: Implications in Multiple Sclerosis-Induced Neuropathic Pain
dc.typeJournal Article
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