Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation

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dc.contributor.authorNoble, Earl G.
dc.contributor.authorShen, Garry X.
dc.date.accessioned2015-05-14T16:25:07Z
dc.date.available2015-05-14T16:25:07Z
dc.date.issued2012-12-17
dc.date.updated2015-03-29T13:30:37Z
dc.description.abstractHeat shock proteins (Hsp) play critical roles in the body’s self-defense under a variety of stresses, including heat shock, oxidative stress, radiation, and wounds, through the regulation of folding and functions of relevant cellular proteins. Exercise increases the levels of Hsp through elevated temperature, hormones, calcium fluxes, reactive oxygen species (ROS), or mechanical deformation of tissues. Isotonic contractions and endurance- type activities tend to increase Hsp60 and Hsp70. Eccentric muscle contractions lead to phosphorylation and translocation of Hsp25/27. Exercise-induced transient increases of Hsp inhibit the generation of inflammatory mediators and vascular inflammation. Metabolic disorders (hyperglycemia and dyslipidemia) are associated with type 1 diabetes (an autoimmune disease), type 2 diabetes (the common type of diabetes usually associated with obesity), and atherosclerotic cardiovascular disease. Metabolic disorders activate HSF/Hsp pathway, which was associated with oxidative stress, increased generation of inflammatory mediators, vascular inflammation, and cell injury. Knock down of heat shock factor-1 (HSF1) reduced the activation of key inflammatory mediators in vascular cells. Accumulating lines of evidence suggest that the activation of HSF/Hsp induced by exercise or metabolic disorders may play a dual role in inflammation. The benefits of exercise on inflammation and metabolism depend on the type, intensity, and duration of physical activity.
dc.description.versionPeer Reviewed
dc.identifier.citationEarl G. Noble and Garry X. Shen, “Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation,” Autoimmune Diseases, vol. 2012, Article ID 836519, 13 pages, 2012. doi:10.1155/2012/836519
dc.identifier.urihttp://dx.doi.org/10.1155/2012/836519
dc.identifier.urihttp://hdl.handle.net/1993/30489
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2012 Earl G. Noble and Garry X. Shen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleImpact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation
dc.typeJournal Article
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