Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population

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dc.contributor.authorHashemi, Mohammad
dc.contributor.authorYousefi, Javad
dc.contributor.authorHashemi, Seyed Mehdi
dc.contributor.authorAmininia, Shadi
dc.contributor.authorEbrahimi, Mahboubeh
dc.contributor.authorTaheri, Mohsen
dc.contributor.authorGhavami, Saeid
dc.date.accessioned2015-05-14T15:27:59Z
dc.date.available2015-05-14T15:27:59Z
dc.date.issued2015-5-3
dc.date.updated2015-05-09T07:05:16Z
dc.description.abstractIt has been suggested that genetic factors contribute to patients’ vulnerability to breast cancer (BC). The programmed cell death 6 interacting protein (PDCD6IP) encodes for a protein that is known to bind to the products of the PDCD6 gene, which is involved in the apoptosis pathway. The aim of this case-control study is to investigate the relationship between the PDCD6IP 15 bp insertion/deletion (I/D) polymorphism (rs28381975) and BC risk in an Iranian population. A total of 491 females, including 266 BC patients and 225 control subjects without cancer, were enrolled into the study. Our findings revealed that the PDCD6IP 15 bp I/D polymorphism decreased the risk of BC in codominant (, 95% –0.65, , I/D versus DD; , 95% –0.88, , I/I versus DD) and dominant (, 95% –0.63, , D/I + I/I versus D/D) tested inheritance models. Also, the PDCD6IP I allele significantly decreased the risk of BC (, 95% –0.78, ) compared to the D allele.
dc.description.versionPeer Reviewed
dc.identifier.citationMohammad Hashemi, Javad Yousefi, Seyed Mehdi Hashemi, et al., “Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population,” Disease Markers, vol. 2015, Article ID 854621, 5 pages, 2015. doi:10.1155/2015/854621
dc.identifier.urihttp://dx.doi.org/10.1155/2015/854621
dc.identifier.urihttp://hdl.handle.net/1993/30442
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2015 Mohammad Hashemi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleAssociation between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population
dc.typeJournal Article
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