Interplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response

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dc.contributor.authorSampathkumar, Raghavan
dc.contributor.authorShadabi, Elnaz
dc.contributor.authorLuo, Ma
dc.date.accessioned2015-05-14T16:38:19Z
dc.date.available2015-05-14T16:38:19Z
dc.date.issued2012-5-16
dc.date.updated2015-03-29T13:33:01Z
dc.description.abstractAs of February 2012, 50 circulating recombinant forms (CRFs) have been reported for HIV-1 while one CRF for HIV-2. Also according to HIV sequence compendium 2011, the HIV sequence database is replete with 414,398 sequences. The fact that there are CRFs, which are an amalgamation of sequences derived from six or more subtypes (CRF27_cpx (cpx refers to complex) is a mosaic with sequences from 6 different subtypes besides an unclassified fragment), serves as a testimony to the continual divergent evolution of the virus with its approximate 1% per year rate of evolution, and this phenomena per se poses tremendous challenge for vaccine development against HIV/AIDS, a devastating disease that has killed 1.8 million patients in 2010. Here, we explore the interaction between HIV-1 and host genetic variation in the context of HIV/AIDS and antiretroviral therapy response.
dc.description.versionPeer Reviewed
dc.identifier.citationRaghavan Sampathkumar, Elnaz Shadabi, and Ma Luo, “Interplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response,” Advances in Virology, vol. 2012, Article ID 508967, 16 pages, 2012. doi:10.1155/2012/508967
dc.identifier.urihttp://dx.doi.org/10.1155/2012/508967
dc.identifier.urihttp://hdl.handle.net/1993/30503
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2012 Raghavan Sampathkumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleInterplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response
dc.typeJournal Article
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