Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide
dc.contributor.author | Waititu, Samuel M | |
dc.contributor.author | Yin, Fugui | |
dc.contributor.author | Patterson, Rob | |
dc.contributor.author | Rodriguez-Lecompte, Juan C | |
dc.contributor.author | Nyachoti, Charles M | |
dc.date.accessioned | 2016-11-04T15:14:49Z | |
dc.date.available | 2016-11-04T15:14:49Z | |
dc.date.issued | 2016-11-03 | |
dc.date.updated | 2016-11-03T17:04:27Z | |
dc.description.abstract | Abstract Background This study investigated the response of piglets receiving a yeast extract without or with a multi-enzyme mixture compared with an antimicrobial growth promoter (AGP) on performance, immune status and gut structure after an E. coli lipopolysaccharide (LPS) challenge. Thirty-six pigs were allotted to six treatments including: a non-challenged control (NCC); LPS-challenged control (CC); CC + AGP; CC + yeast extract; CC + enzymes; and CC + enzymes + yeast extract. On d 7, pigs were bled and thereafter injected with LPS or sterile saline. Blood samples were collected at 6, 48, and 96 h post-challenge. After 96 h post-challenge, pigs were euthanized to obtain duodenal, jejunal and ileal samples. Results Overall (d 1 to 11), compared with CC pigs, AGP attenuated the LPS-induced reduction in ADG (P = 0.004), ADFI (P = 0.03) and gain/feed ratio (P = 0.01). At 6 h post-challenge, AGP pigs had lower plasma urea N (PUN; P = 0.02) and serum TNF- α concentration (P = 0.07), and higher platelet count (P = 0.04) and serum IL-10 concentration (P = 0.02) than CC pigs. At 48 h post-challenge, AGP pigs had lower PUN (P = 0.02) than CC pigs, whereas enzymes + yeast extract interacted non-additively (P = 0.001) to reduce PUN. At 96 h post-challenge, AGP pigs had lower PUN (P = 0.02) and higher duodenal (P = 0.03), jejunal (P = 0.01) and ileal (P = 0.07) villus height than CC pigs. In addition, enzymes + yeast extract interacted additively and non-additively to reduce ileal IFN-γ (P < 0.0001) and IL-10 (P = 0.012) expression, respectively. Generally, no differences (P > 0.10) were observed between AGP and enzymes + yeast extract pigs on other measured parameters except for the downregulation of ileal IFN-γ (P < 0.0001) and TNF-α (P = 0.003) in enzymes + yeast extract pigs at 96 h post-challenge. Conclusions The LPS challenged piglets receiving enzymes + yeast extract showed beneficial responses in gut structure and immunity commensurate with those receiving antibiotics, though the latter had better overall growth performance. | |
dc.identifier.citation | Journal of Animal Science and Biotechnology. 2016 Nov 03;7(1):64 | |
dc.identifier.uri | http://dx.doi.org/10.1186/s40104-016-0125-5 | |
dc.identifier.uri | http://hdl.handle.net/1993/31924 | |
dc.language.rfc3066 | en | |
dc.rights | open access | en_US |
dc.rights.holder | The Author(s). | |
dc.title | Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide | |
dc.type | Journal Article |