Vascular Compromise and Hemodynamics in Pulmonary Arterial Hypertension: Model Predictions

Simple item page
dc.contributor.authorBshouty, Zoheir
dc.date.accessioned2016-06-07T19:21:08Z
dc.date.available2016-06-07T19:21:08Z
dc.date.issued2012-1-1
dc.date.updated2016-06-07T06:54:33Z
dc.description.abstractA previously validated computer model of the normal pulmonary circulation is adapted to simulate pulmonary arterial hypertension (PAH) in humans. Model predictions are used to explore the suitability of currently accepted criteria for diagnosing PAH by correlating hemodynamic data with the degree of vascular compromise (disease severity).Model predictions demonstrate a hyperbolic relationship between vascular compromise, mean pulmonary artery pressure (PAPm) and pulmonary vascular resistance (PVR). PAPm and PVR change very little from disease initiation until a vascular compromise of 65% to 70% (surface area of 0.35 to 0.3 of baseline, respectively) is reached. Following that, further compromise is associated with a steep rise in PAPm and PVR.The relationship between vascular compromise and hemodynamics may explain the relative stability of cardiac output early in this disease process and, therefore, the lack of symptoms. It also explains the rapid deterioration following diagnosis if the disease remains untreated.Model predictions demonstrate the inadequacy of the current hemodynamic criteria for diagnosing PAH over a wide range of left atrial pressure and cardiac output combinations and for early detection of disease. The model provides an alternative approach to diagnosing PAH by translating hemodynamic data to degree of vascular compromise.
dc.description.versionPeer Reviewed
dc.identifier.citationZoheir Bshouty, “Vascular Compromise and Hemodynamics in Pulmonary Arterial Hypertension: Model Predictions,” Canadian Respiratory Journal, vol. 19, no. 3, pp. 209-215, 2012. doi:10.1155/2012/764545
dc.identifier.urihttp://dx.doi.org/10.1155/2012/764545
dc.identifier.urihttp://hdl.handle.net/1993/31353
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleVascular Compromise and Hemodynamics in Pulmonary Arterial Hypertension: Model Predictions
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
CRJ.2012.764545.xml
Size:
4.34 KB
Format:
Extensible Markup Language
Description:
Download
Thumbnail Image
Name:
CRJ.2012.764545.pdf
Size:
1.07 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.24 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
University of Manitoba Scholarship
Rady Faculty of Health Sciences Scholarly Works