Background: Existing literature on employment for people with disabilities in Nigeria indicates that there is poor rate of employment of this group, and the few that are employed do not enjoy job satisfaction, neither do they get sufficient support from the state. Purpose: This thesis seeks to investigate how the history of Nigeria, and the culture of the southwest Nigeria, enhance disabling conditions around employment of citizens with disabilities. Method: This study utilized a mixed methods design involving a combination of qualitative descriptive approach and a review of existing literature on the history and culture of Southwest Nigeria. Seven participants with mobility impairments, employed in both private and government institutions in Southwest Nigeria participated in this study. Data analysis was performed using NVivo Qualitative Data Analysis software. Findings: The results of this study show that history of Nigeria and culture of southwest Nigeria have major influences on the parameters of employment for people with disabilities. This group experience disablement in employment as a result of physical and attitudinal barriers, discrimination and lack of protection in un-implemented legislation. Employment was found to be a protective factor for both physical and psychological health of persons with disabilities. Conclusions: By combating disabling cultural beliefs, ableist attitudes, discrimination and lack of accessibility within the society, people with disabilities may be opportuned to contribute significantly to the society through their employment.