The relationship between well-being and spatial preference is biologically ingrained. Thus, determining what fuels the individual at a rudimentary level is critical to creating meaningful and emotional space. This practicum seeks to explore, understand, and determine ways our physical, psychological, and environmental needs can be achieved within an urban commercial interior. Concepts of home, survival, place, authenticity, and aesthetic experience are applied to the design of an urban winery. These attitudes include an embrace of cultural heritage as a crucial part of a creative and authentic design process, a demand for design that supports sensory experience, and a desire to provoke physiological, cognitive, and aesthetic fulfillment in the end user. The literature is engaged from an existential perspective to inform conceptual innovations in interior design, specifically focusing on the human condition. The findings consolidate to determine how interior design can a) utilize human motivation to create effective and meaningful design strategies; b) assist in the promotion and preservation of tangible and intangible heritage; and c) translate and sustain the experiential nature of wine, and its sensory and aesthetic phenomena, via spatial experience.