Hepatitis B Viral Mutants and Their Relevance to the Canadian Health Care System

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dc.contributor.authorMinuk, Gerald Y
dc.date.accessioned2016-06-01T16:44:16Z
dc.date.available2016-06-01T16:44:16Z
dc.date.issued2002-1-1
dc.date.updated2016-05-09T09:03:25Z
dc.description.abstractOver the past 10 years, an increasing number of mutations in the hepatitis B virus genome have been described. While the majority of these mutations appear to be ‘silent’ or not clinically relevant, some have been described in association with increased severity of disease (core and basic core promoter mutations), evasion of immunological surveillance (S escape mutants), hepatocellular carcinogenesis (X mutants) and resistance to antiviral agents (DNA polymerase mutations). The molecular events and the clinical consequences thereof are reviewed.
dc.description.versionPeer Reviewed
dc.identifier.citationGerald Y Minuk, “Hepatitis B Viral Mutants and Their Relevance to the Canadian Health Care System,” Canadian Journal of Gastroenterology, vol. 16, no. 1, pp. 45-54, 2002. doi:10.1155/2002/516172
dc.identifier.urihttp://dx.doi.org/10.1155/2002/516172
dc.identifier.urihttp://hdl.handle.net/1993/31311
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2002 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http://creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.
dc.titleHepatitis B Viral Mutants and Their Relevance to the Canadian Health Care System
dc.typeJournal Article
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