Alzheimer's disease: an evaluation of memory and neuropathology in the TgCRND8 transgenic mouse model

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dc.contributor.authorGlazner, Kathryn A.C.
dc.contributor.examiningcommitteeAmara, Francis (Biochemistry & Medical Genetics) Smyth, Donald (Pharmacology & Therapeutics)en_US
dc.contributor.supervisorAlbensi, Benedict (Pharmacology & Therapeutics)en_US
dc.date.accessioned2011-09-08T14:48:35Z
dc.date.available2011-09-08T14:48:35Z
dc.date.issued2010-06-19
dc.degree.disciplinePharmacology and Therapeuticsen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractAlzheimer’s disease (AD) is a neurologically debilitating disease that is plaguing our elderly population. Transgenic mice with Alzheimer’s disease mutations are used to study signal pathways, potential drug targets and mechanism of disease. However, studies of the effects of different AD mutations on behavior and neuropathological progression in mice have been inconsistent when comparing different genetic backgrounds. The aim of this study was to compare two commonly used TgCRND8 backgrounds, the 129SvEvtac/C57F1 and C3H/C57F1 strains, for memory function in the Morris water maze (MWM), and to determine differences in plaque burden. We found deficits in multiple parameters of the MWM in the 129SvEvtac/C57F1 strain. Similarly, this background strain showed significantly more amyloid beta (Aβ) plaque burden than the C3H/C57F1 strain. This supports the hypothesis that strain specific differences are apparent in spatial memory testing and neuropathologic progression of AD. It leads us to believe that epigenetics are key to understanding AD risk assessment and development.en_US
dc.description.noteOctober 2011en_US
dc.identifier.citationStrain specific differences in memory and neuropathology in a mouse model of Alzheimer's diseaseen_US
dc.identifier.citationHistochemical visualization and diffusion MRI at 7 Tesla in the TgCRND8 transgenic model of Alzheimer's diseaseen_US
dc.identifier.urihttp://hdl.handle.net/1993/4851
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.publisherSpringeren_US
dc.rightsopen accessen_US
dc.subjectTgCRND8en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectmemoryen_US
dc.titleAlzheimer's disease: an evaluation of memory and neuropathology in the TgCRND8 transgenic mouse modelen_US
dc.typemaster thesisen_US
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