The cardio-renal effect of pea protein hydrolysate in a chronic kidney disease rat model

Simple item page
dc.contributor.authorPrairie, Natalie Paula
dc.contributor.examiningcommitteeZahradka, Peter (Human Nutritional Sciences) Kirshenbaum, Lorrie (Physiology)en_US
dc.contributor.supervisorAukema, Harold (Human Nutritional Sciences) Tappia, Paramjit (Human Nutritional Sciences)en_US
dc.date.accessioned2012-01-03T17:42:58Z
dc.date.available2012-01-03T17:42:58Z
dc.date.issued2012-01-03
dc.degree.disciplineHuman Nutritional Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractPea protein hydrolysate (PPH) has antihypertensive effects and prostanoids have been implicated in renal diseases. To investigate the role of PPH and prostanoids on renal and cardiovascular effects in cardio-renal disease, normal and diseased Han:SPRD-cy rats were given diets containing either 0, 0.5% or 1% PPH for 8 weeks. At termination, diseased rat kidneys displayed increased renal cyst growth, fibrosis, plasma creatinine and lower monocyte chemoattractant protein-1. Diseased rats also exhibited left ventricular (LV) hypertrophy, elevated systolic and diastolic blood pressures and LV end diastolic and systolic pressures. Four of five prostanoids were elevated in diseased rat kidneys. PPH attenuated systolic blood pressure, but not other components of the cardio-renal syndrome. PPH also increased select prostanoids in normal and diseased rats. Thus, dietary PPH attenuates hypertension in the Han:SPRD-cy rat, but does not ameliorate other components of disease, possibly due to increased prostanoid effects or an insufficient treatment length.en_US
dc.description.noteOctober 2011en_US
dc.identifier.urihttp://hdl.handle.net/1993/5015
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectpea protein hydrolysateen_US
dc.subjectHan:SPRD-cy raten_US
dc.subjectchronic kidney diseaseen_US
dc.subjectangiotensin converting enzymeen_US
dc.subjectreninen_US
dc.titleThe cardio-renal effect of pea protein hydrolysate in a chronic kidney disease rat modelen_US
dc.typemaster thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Prairie_Natalie.pdf
Size:
1.21 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.25 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
FGS - Electronic Theses and Practica