Surface modification of bio-implantable Ti-6Al-4V alloy for enhanced osseointegration and antibacterial capability
| dc.contributor.author | Wang, Ziyuan | |
| dc.contributor.examiningcommittee | Richards, Norman (Mechanical Engineering) Yi, Ann (Pediatrics and Child Health) | en_US |
| dc.contributor.supervisor | Ojo, Olanrewaju (Mechanical Engineering) Xing, Malcolm (Mechanical Engineering) | en_US |
| dc.date.accessioned | 2014-06-26T14:36:59Z | |
| dc.date.available | 2014-06-26T14:36:59Z | |
| dc.date.issued | 2014-06-26 | |
| dc.degree.discipline | Mechanical and Manufacturing Engineering | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Surface-induced osseointegration and antibacterial capability are very important criteria for the clinical success of titanium implants. To enhance these two criteria, an architectural hybrid system is constructed onto Ti-6Al-4V with a rough surface. First, thermal oxidation (TO), treatment with hydrogen peroxide (H2O2) and a mix of TO and H2O2 (Mixed) are used to modify the surface topography and chemistry of Ti-6Al-4V disks. Surface characterizations by the use of microscopes and spectroscopes indicate that TO can induce more favorable topography, roughness, wettability and hydroxyl group concentration on Ti-6Al-4V surfaces. Therefore, an alginate/chitosan LBL film that incorporates antibacterial nano-silver is bridged onto thermally oxidized Ti-6Al-4V alloy by mussel-inspired dopamine. The microscopies and spectrometers confirm that the hybrid system is successfully fabricated onto the Ti-6Al-4V surface while the sub-micron topography induced by TO is maintained. Bone marrow stem cell (BMSC) adhesion, proliferation and differentiation are up-regulated by the synergy of sub-micron surface produced by TO and alginate/chitosan LBL film. The incorporation of nano-silver into the hybrid system is demonstrated to inhibit the growth of Escherichia coli and Staphylococcus aureus, but not jeopardize the enhanced BMSC activities. Taken together, this thesis presents a promising strategy to fabricate novel Ti-6Al-4V implants with enhanced osseointegration and antibacterial capability. | en_US |
| dc.description.note | October 2014 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/23666 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Surface modification | en_US |
| dc.subject | osseointegration | en_US |
| dc.subject | Antibacterial | en_US |
| dc.subject | Ti-6Al-4V | en_US |
| dc.title | Surface modification of bio-implantable Ti-6Al-4V alloy for enhanced osseointegration and antibacterial capability | en_US |
| dc.type | master thesis | en_US |