H1 antihistamines: current status and future directions

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dc.contributor.authorSimon, F Estelle R
dc.contributor.authorSimons, Keith J
dc.date.accessioned2013-03-01T16:04:52Z
dc.date.available2013-03-01T16:04:52Z
dc.date.issued2008-09-15
dc.date.updated2013-03-01T16:04:52Z
dc.description.abstractAbstract In this review, we compare and contrast the clinical pharmacology, efficacy, and safety of first-generation H1 antihistamines and second-generation H1 antihistamines. First-generation H1 antihistamines cross the blood-brain barrier, and in usual doses, they potentially cause sedation and impair cognitive function and psychomotor performance. These medications, some of which have been in use for more than 6 decades, have never been optimally investigated. Second-generation H1 antihistamines such as cetirizine, desloratadine, fexofenadine, levocetirizine, and loratadine cross the blood-brain barrier to a significantly smaller extent than their predecessors. The clinical pharmacology, efficacy, and safety of these medications have been extensively studied. They are therefore the H1 antihistamines of choice in the treatment of allergic rhinitis, allergic conjunctivitis, and urticaria. In the future, clinically advantageous H1 antihistamines developed with the aid of molecular techniques might be available.
dc.description.versionPeer Reviewed
dc.identifier.citationWorld Allergy Organization Journal. 2008 Sep 15;1(9):145-155
dc.identifier.doihttp://dx.doi.org/10.1097/WOX.0b013e3181865f99
dc.identifier.urihttp://hdl.handle.net/1993/16853
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderF Estelle R Simon et al.; licensee BioMed Central Ltd.
dc.titleH1 antihistamines: current status and future directions
dc.typeJournal Article
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