The association of caveolae, actin, and the dystrophin-glycoprotein complex: a role in smooth muscle phenotype and function?

Simple item page
dc.contributor.authorHalayko, AJ
dc.contributor.authorStelmack, GL
dc.date.accessioned2007-10-05T12:17:16Z
dc.date.available2007-10-05T12:17:16Z
dc.date.issued2005-10-31
dc.description.abstractSmooth muscle cells exhibit phenotypic and mechanical plasticity. During maturation, signalling pathways controlling actin dynamics modulate contractile apparatus-associated gene transcription and contractile apparatus remodelling resulting from length change. Differentiated myocytes accumulate abundant caveolae that evolve from the structural association of lipid rafts with caveolin-1, a protein with domains that confer unique functional properties. Caveolae and caveolin-1 modulate and participate in receptor-mediated signalling, and thus contribute to functional diversity of phenotypically similar myocytes. In mature smooth muscle, caveolae are partitioned into discrete linear domains aligned with structural proteins that tether actin to the extracellular matrix. Caveolin-1 binds with beta-dystroglycan, a subunit of the dystrophin glycoprotein complex (DGC), and with filamin, an actin binding protein that organizes cortical actin, to which integrins and focal adhesion complexes are anchored. The DGC is linked to the actin cytoskeleton by a dystrophin subunit and is a receptor for extracellular laminin. Thus, caveolae and caveolin-associated signalling proteins and receptors are linked via structural proteins to a dynamic filamentous actin network. Despite development of transgenic models to investigate caveolins and membrane-associated actin-linking proteins in skeletal and cardiac muscle function, only superficial understanding of this association in smooth muscle phenotype and function has emerged.en
dc.format.extent527339 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citation0008-4212; CAN J PHYSIOL PHARMACOL, OCT 2005, vol. 83, no. 10, p.877 to 891.en
dc.identifier.doihttps://doi.org/10.1139/y05-107
dc.identifier.urihttp://hdl.handle.net/1993/2889
dc.language.isoengen_US
dc.rightsNo part of the NRC Research Press electronic journals may be reproduced, stored, or transmitted in any form or by any means, without the written permission of the publisher, except as stated below. Under the Canadian Copyright Act, individuals may download or print single copies of articles for personal research or study. Any person may reproduce short excerpts from articles in the journals for any purpose that respects the moral rights of authors, provided that the source is fully acknowledged. As a courtesy, the consent of authors of such material should be obtained directly from the author. Authorization to reproduce items for other than personal research or study, as stated above, may be obtained via Access © upon payment of the copyright fee of $10.00 per copy. NRC Research Press also extends certain additional rights to authors. The above rights do not extend to copying or reproduction for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. For such copying or reproduction, arrangements must be made with NRC Research Press.en
dc.rightsopen accessen_US
dc.statusPeer revieweden
dc.subjectcaveolinen
dc.subjectdystroglycanen
dc.subjectfilaminen
dc.subjectmechanical plasticityen
dc.subjectG-protein-coupled receptorsen
dc.subjectSARCOGLYCAN-SARCOSPAN COMPLEXen
dc.subjectPROTEIN-COUPLED RECEPTORen
dc.subjectLIGHT-CHAIN PHOSPHATASEen
dc.subjectSERUM RESPONSE FACTORen
dc.subjectOPERATED CA2+ ENTRYen
dc.subjectMAP KINASE CASCADEen
dc.subjectVASCULAR SMOOTHen
dc.subjectMUSCULAR-DYSTROPHYen
dc.subjectMECHANICAL STRAINen
dc.subjectBETA-DYSTROGLYCANen
dc.titleThe association of caveolae, actin, and the dystrophin-glycoprotein complex: a role in smooth muscle phenotype and function?en
dc.typejournal articleen_US
Files
Collections
University of Manitoba Scholarship (login required)