Molecular mechanism of the Fibroblast Growth Factor Receptor, egl-15, and α-integrin receptor, ina-1, in gland cell migration during embryonic development of the Caenorhabditis elegans pharynx

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dc.contributor.authorKim, Shinhye
dc.contributor.examiningcommitteeWhyard, Steve (Biological Sciences) Merz, David (Biochemistry & Medical Genetics)en_US
dc.contributor.supervisorKormish, Jay (Biological Sciences)en_US
dc.date.accessioned2015-01-21T15:06:06Z
dc.date.available2015-01-21T15:06:06Z
dc.date.issued2015-01-21
dc.degree.disciplineBiological Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractCaenorhabditis elegans is a powerful tool to study cellular migration and morphogenesis during organ development. During pharynx development, the dorsal gland cell, g1p, is born in the anterior aspect of the pharyngeal primordium and undergoes a form of morphogenesis called retrograde extension. egl-15, the single Fibroblast Growth Factor Receptor (FGFR) in C. elegans and ina-1, one of two α-integrin receptors, are both required for the proper extension or migration of g1p cell. Mutations in either egl-15 or ina-1 show similar gland cell over-migration defects where the gland cell body migrates past the terminal bulb and is located in proximity of the intestine. The kinase domain of EGL-15 was found to be required for migration and transgenic rescue strategies were used to determine the tissue of EGL-15 function. RNA interference was used to determine if egl-15 and ina-1 are functioning in the same pathway to regulate gland cell migration.en_US
dc.description.noteFebruary 2015en_US
dc.identifier.urihttp://hdl.handle.net/1993/30238
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectcell migrationen_US
dc.subjectorganogenesisen_US
dc.subjectegl-15/FGFRen_US
dc.subjectina-1/alpha-integrinen_US
dc.subjectretrograde extensionen_US
dc.subjectpharynxen_US
dc.titleMolecular mechanism of the Fibroblast Growth Factor Receptor, egl-15, and α-integrin receptor, ina-1, in gland cell migration during embryonic development of the Caenorhabditis elegans pharynxen_US
dc.typemaster thesisen_US
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