Sex-specific associations of human milk long-chain polyunsaturated fatty acids and infant allergic conditions

Simple item page
dc.contributor.authorMiliku, Kozeta
dc.contributor.authorRichelle, Jacqueline
dc.contributor.authorBecker, Allan B
dc.contributor.authorSimons, Elinor
dc.contributor.authorMoraes, Theo J.
dc.contributor.authorTurvey, Stuart E.
dc.contributor.authorMandhane, Piush J.
dc.contributor.authorField, Catherine J
dc.contributor.authorAzad, Meghan
dc.date.accessioned2022-08-18T14:58:47Z
dc.date.available2022-08-18T14:58:47Z
dc.date.issued2021-03-12
dc.date.submitted2022-08-17T20:33:18Zen_US
dc.description.abstractBackground Polyunsaturated fatty acids (PUFAs) may influence immune development. We examined the association of PUFAs in human milk with food sensitization and atopic dermatitis among breastfed infants. Methods In a selected subgroup of 1109 mother-infant dyads from the CHILD Cohort Study, human milk was analyzed by gas-liquid chromatography to quantify PUFAs including arachidonic acid (ARA) and docosahexaenoic acid (DHA). At 1 year of age, food sensitization was determined by skin-prick testing for egg, peanut, cow's milk, and soybean, and atopic dermatitis was diagnosed by pediatricians. Logistic regression analyses controlled for breastfeeding exclusivity, family history of atopy, and other potential confounders. Results Overall, 184 infants (17%) were sensitized to one or more food allergens and 160 (14%) had atopic dermatitis. Sex-specific associations were observed between these conditions and milk PUFAs. Girls receiving human milk with lower proportions of DHA had lower odds of food sensitization (aOR 0.35; 95% CI 0.12, 0.99 for lowest vs highest quintile), and a clear dose-dependent association was observed for the ARA/DHA ratio (aOR 2.98; 95% CI 1.10, 8.06 for lowest vs highest quintile). These associations were not seen in boys. Similar sex-specific tendencies were observed for atopic dermatitis. Conclusions Human milk PUFA proportions and their ratios are associated with infant atopic conditions in a sex-specific manner. In female infants, a higher ratio of ARA/DHA may reduce the risk of food sensitization and atopic dermatitis. Further research is needed to determine the underlying mechanisms and clinical relevance of this sex-specific association.en_US
dc.description.sponsorshipThis research was funded by the Manitoba Medical Service Foundation and the Children's Hospital Research Institute of Manitoba. The Canadian Institutes of Health Research (CIHR) and the Allergy, Genes and Environment (AllerGen) Network provided core funding for the CHILD Cohort Study. KM received funding from the Canadian Lung Association. This research was supported in part by the Canada Research Chairs (CRC) Program. MBA holds a Canada Research Chair in the Developmental Origins of Chronic Disease, and is a CIFAR fellow in the Humans and the Microbiome Program.en_US
dc.identifier.doi10.1111/pai.13500
dc.identifier.urihttp://hdl.handle.net/1993/36705
dc.language.isoengen_US
dc.publisherPediatric Allergy and Immunologyen_US
dc.rightsopen accessen_US
dc.subjectAtopic Dermatitisen_US
dc.subjectBreastfeedingen_US
dc.subjectHuman Milken_US
dc.subjectFood Sensitizationen_US
dc.subjectPolyunsaturated Fatty Acidsen_US
dc.titleSex-specific associations of human milk long-chain polyunsaturated fatty acids and infant allergic conditionsen_US
dc.typepreprinten_US
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Pediatrics and Child Healthen_US
oaire.citation.endPage1182en_US
oaire.citation.issue6en_US
oaire.citation.startPage1173en_US
oaire.citation.titlePediatric Allergy and Immunologyen_US
oaire.citation.volume32en_US
project.funder.identifierhttp://dx.doi.org/10.13039/100008795en_US
project.funder.nameManitoba Medical Service Foundationen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Sex-specific associations of human milk long-chain polyunsaturated fatty acids and infant allergic conditions.pdf
Size:
674.43 KB
Format:
Adobe Portable Document Format
Description:
Accepted Manuscript
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.24 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
University of Manitoba Scholarship
Rady Faculty of Health Sciences Scholarly Works