The issue of employment is critical to the survival of every human being. However, the employment of women with vision impairment and their integration into the formal sector of the labour market is low. This is especially true in Ghana where policies such as the Ghana Disability Act 715, which was passed in 2006 and meant to target the removal of barriers in the socioeconomic participation of persons with disabilities has produced no significant results. The purpose of this qualitative study was to explore the lived experiences of women with vision impairment seeking employment by focusing on their lived experiences and the barriers they face when seeking employment. By using interpretive description, ten purposefully selected women with vision impairment in Kumasi, Ghana shared their experiences through semi-structured interviews. By employing thematic analysis, data obtained was coded and categorized to identify themes. Four themes were developed using thematic analysis: 1) Treated like we are not human, 2) Limited opportunities and support for workforce participation, 3) Expected to fulfill gender roles and 4) Valued social supports. At the end of the study, it was found that the Ghanaian culture exerted an enormous influence on society’s attitude towards the employment of women with vision impairment. Areas such as preparation, training and accommodation were identified as limiting factors in the employment participation of women with vision impairment in Ghana. Therefore, to mitigate these barriers there is the need for continuous public education on disability and the provision of incentives to organizations and establishments that employ women with vision impairment.