Claudin 1 in Breast Tumorigenesis: Revelation of a Possible Novel “Claudin High” Subset of Breast Cancers

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dc.contributor.authorMyal, Yvonne
dc.contributor.authorLeygue, Etienne
dc.contributor.authorBlanchard, Anne A.
dc.date.accessioned2015-03-31T17:24:33Z
dc.date.available2015-03-31T17:24:33Z
dc.date.issued2010-5-13
dc.date.updated2015-03-29T13:38:41Z
dc.description.abstractClaudins are the major component of the tight junctions in epithelial cells and as such play a key role in the polarized location of ion channels, receptors, and enzymes to the different membrane domains. In that regard, claudins are necessary for the harmonious development of a functional epithelium. Moreover, defective tight junctions have been associated with the development of neoplastic phenotype in epithelial cells. Breakdown of cell-cell interactions and deregulation of the expression of junctional proteins are therefore believed to be key steps in invasion and metastasis. Several studies suggest that the claudins are major participants in breast tumorigenesis. In this paper, we discuss recent advances in our understanding of the potential role of claudin 1 in breast cancer. We also discuss the significance of a subset of estrogen receptor negative breast cancers which express “high” levels of the claudin 1 protein. We propose that claudin 1 functions both as a tumor suppressor as well as a tumor enhancer/facilitator in breast cancer.
dc.description.versionPeer Reviewed
dc.identifier.citationYvonne Myal, Etienne Leygue, and Anne A. Blanchard, “Claudin 1 in Breast Tumorigenesis: Revelation of a Possible Novel “Claudin High” Subset of Breast Cancers,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 956897, 9 pages, 2010. doi:10.1155/2010/956897
dc.identifier.urihttp://dx.doi.org/10.1155/2010/956897
dc.identifier.urihttp://hdl.handle.net/1993/30318
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2010 Yvonne Myal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleClaudin 1 in Breast Tumorigenesis: Revelation of a Possible Novel “Claudin High” Subset of Breast Cancers
dc.typeJournal Article
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