The in vitro evaluation of the effect of Linezolid and Levofloxacin on Bacillus anthracis toxin production, spore formation and cell growth

Simple item page
dc.contributor.authorHead, Breanne
dc.contributor.examiningcommitteeBall, Blake (Medical Microbiology) Sitar, Daniel (Pharmacology and Therapeutics)en_US
dc.contributor.supervisorMeyers, Adrienne (Medical Microbiology) Alfa, Michelle (Medical Microbiology)en_US
dc.date.accessioned2015-07-30T19:42:55Z
dc.date.available2015-07-30T19:42:55Z
dc.date.issued2015
dc.degree.disciplineMedical Microbiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractBacillus anthracis, the etiological agent of anthrax, is a spore- forming, toxin- producing bacterium. Currently, treatment of B. anthracis infections requires a 60- day antibiotic regimen. However, better therapeutics are required. Therefore, this study looked at the effect of levofloxacin and linezolid on B. anthracis cell viability, toxin production and spore formation using in vitro static models and a pharmacodynamic model. It was hypothesized that the combination would be the most effective at preventing toxin and spore production resulting in greater bacterial killing. However, these studies suggest otherwise. Nevertheless, clinically, the combination therapy may be more effective in rapid killing of vegetative B. anthracis and may be able to reduce the duration of therapy (by reducing the likelihood of spore survival). Therefore, the clinical benefit of combined therapy on long-term recurrence cannot be determined from these in vitro models. Further investigation with combination therapy is warranted.en_US
dc.description.noteOctober 2015en_US
dc.identifier.urihttp://hdl.handle.net/1993/30646
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectBacillus anthracisen_US
dc.subjectlinezoliden_US
dc.subjectlevofloxacinen_US
dc.subjecttoxinen_US
dc.subjectsporeen_US
dc.subjectanthraxen_US
dc.subjectantibioticsen_US
dc.subjectbacillusen_US
dc.titleThe in vitro evaluation of the effect of Linezolid and Levofloxacin on Bacillus anthracis toxin production, spore formation and cell growthen_US
dc.typemaster thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Head_Breanne.pdf
Size:
1.13 MB
Format:
Adobe Portable Document Format
Description:
Thesis
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.25 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
FGS - Electronic Theses and Practica