Antigenic induction of nerve growth factor (NGF) in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS)

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dc.contributor.authorAcosta, Crystal May R.
dc.contributor.examiningcommitteeMacNeil, Brian (Medical Rehabilitation) Burczynski, Frank (Pharmacy)en_US
dc.contributor.supervisorNamaka, Mike (Pharmacy)en_US
dc.date.accessioned2014-04-14T20:07:22Z
dc.date.available2014-04-14T20:07:22Z
dc.date.issued2013en_US
dc.date.issued2013en_US
dc.date.issued2014en_US
dc.degree.disciplinePharmacyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractNerve growth factor (NGF) represents a new therapeutic strategy for multiple sclerosis (MS) because of its immunomodulatory and neuroprotective activity. To analyze changes in NGF expression experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats. In the dorsal root ganglia (DRG) of animals with EAE, NGF mRNA and protein increased between 18 - 24 days post induction (dpi) during complete neurological recovery. In the spinal cord (SC) of animals with EAE, NGF mRNA and protein expression increased at 15 dpi and 12 dpi, respectively, to reduce EAE-induced disability. We identified the 25 kDa pro-NGF as a biologically active isoform during EAE. EAE SC axons demonstrate a loss or thinning of myelin which correlated with maximal neurological disability. NGF plays a role in minimizing EAE-induced inflammation and myelin damage to promote neurological recovery. NGF may be an “off switch” for a cytokine-neurotrophin signaling triad to govern the extent of myelin damage.en_US
dc.description.noteMay 2014en_US
dc.identifier.citation1. C.M.R. Acosta., C. Cortes, H. Macphee, and M.P. Namaka, Exploring the Role of Nerve Growth Factor in Multiple Sclerosis: Implications in Myelin Repair. CNS & Neurolological Disorders – Drug Targets. 2013: p. 1242-1256en_US
dc.identifier.citation2. W. Zhu, C. Acosta, B. MacNeil, C. Cortes, H. Intrater, Y. Gong, and M. Namaka, Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain. Biomed Res Int. 2013: p. 48070en_US
dc.identifier.citation3. W. Zhu, C. Acosta, B.J. MacNeil, C. Cortes, M.Doupe, Y.Gong, M. Namaka. Spinal Cord Brain Derived Neurotrophic Factor (BDNF) Responsive Cells in an Experimental Autoimmune Encephalomyelitis (EAE) Model of Multiple Sclerosis (MS): Implications in Myelin Repair. Research in Immunology: An International Journal. 2014en_US
dc.identifier.urihttp://hdl.handle.net/1993/23504
dc.language.isoengen_US
dc.publisherBentham Scienceen_US
dc.publisherHindawi Publishingen_US
dc.publisherIBIMA Publishingen_US
dc.rightsopen accessen_US
dc.subjectMSen_US
dc.subjectNGFen_US
dc.subjectNeurodegenerationen_US
dc.subjectNeuroimmunologyen_US
dc.titleAntigenic induction of nerve growth factor (NGF) in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS)en_US
dc.typemaster thesisen_US
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