Dual-functional polyurea microcapsules for chronic wound care dressings: sustained drug delivery and non-leaching infection control

Simple item page
dc.contributor.authorHe, Wei
dc.contributor.examiningcommitteeGu, Xiaochen (Faculty of Pharmacy) Zhong, Wen (Textile Sciences)en_US
dc.contributor.supervisorLiu, Song (Textile Sciences)en_US
dc.date.accessioned2012-08-20T21:31:46Z
dc.date.available2012-08-20T21:31:46Z
dc.date.issued2012-06-12en_US
dc.degree.disciplineTextile Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractA new design of dual-functional polyurea microcapsules was proposed for chronic wound dressings to provide both non-leaching infection control and sustained topical drug delivery functionalities. Quaternary ammonium functionalized polyurea microcapsules (MCQs) were synthesized under mild conditions through an interfacial crosslinking reaction between branched polyethylenimine (PEI) and 2,4-toluene diisocyanate (TDI) in a dimethylformamide/cyclohexane emulsion. An in-situ modification method was developed to endow non-leaching surface antimicrobial properties to MCQs via bonding antimicrobial surfactants to surface isocyanate residues on the polyurea shells. The resultant robust MCQs with both non-leaching antimicrobial properties and sustained drug releasing properties have potential applications in medical textiles, such as chronic wound dressings, for infection control and drug delivery.en_US
dc.description.noteOctober 2012en_US
dc.identifier.citationHe, W., Gu, X. and Liu, S. (2012), Surfactant-Free One-Step Synthesis of Dual-Functional Polyurea Microcapsules: Contact Infection Control and Drug Delivery. Adv. Funct. Mater.. doi: 10.1002/adfm.201200656en_US
dc.identifier.urihttp://hdl.handle.net/1993/8443
dc.language.isoengen_US
dc.publisherJohn Wiley and Sonsen_US
dc.rightsopen accessen_US
dc.subjectmicrocapsuleen_US
dc.subjectwound dressingen_US
dc.subjectpolyureaen_US
dc.subjectchronic wounden_US
dc.titleDual-functional polyurea microcapsules for chronic wound care dressings: sustained drug delivery and non-leaching infection controlen_US
dc.typemaster thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
He_Wei.pdf
Size:
2.32 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.25 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
FGS - Electronic Theses and Practica