Effectiveness of C1-INH therapy in angiotensin converting enzyme inhibitor induced angioedema
| dc.contributor.author | Kovaltchouk, Uliana | |
| dc.contributor.author | Zhang, Boyang | |
| dc.contributor.author | Jain, Vipul | |
| dc.contributor.author | Kalicinsky, Chrystyna | |
| dc.date.accessioned | 2021-03-01T05:20:50Z | |
| dc.date.issued | 2021-02-15 | |
| dc.date.updated | 2021-03-01T05:20:50Z | |
| dc.description.abstract | Abstract Introduction Angiotensin Converting Enzyme Inhibitors (ACEI) are a common cause of Emergency Room presentation for angioedema. Although no treatment guidelines exist, C1 esterase inhibitor concentrate (C1-INH) is used on an off label basis for management of ACEI acquired angioedema (ACEI AAE). Objective To evaluate the efficacy of C1-INH in management of ACEI AAE at our local centers. Results Nine patients, from 3 academic sites, were identified through Allergy Service consultation data and records from Diagnostic Services Manitoba, Canada from 2010–2020. The majority of the patients (n = 8/9) required endotracheal intubation prior to the initiation of C1-INH. Overall, approximately 56% of patients (n = 5/9) had resolution of angioedema ranging between 12 and 17 h, with a median time of 13.5 h, and no recurrence after the administration of C1-INH concentrate. One patient had transient symptom resolution in 14 h, however, recurrence of angioedema required re-intubation. The remainder of patients (n = 4/9), had resolution of angioedema between 22 and 72 h, with a median time of 33.75 h. Conclusion Our findings demonstrate continued ambivalence of the efficacy and role of C1-INH concentrate in the treatment of ACEI AAE, secondary to multiple uncontrolled confounding factors. Further research into characterizing a subgroup of intubated patients in our study that responded to C1-INH concentrate needs to be completed. | |
| dc.identifier.citation | Allergy, Asthma & Clinical Immunology. 2021 Feb 15;17(1):18 | |
| dc.identifier.uri | https://doi.org/10.1186/s13223-021-00521-w | |
| dc.identifier.uri | http://hdl.handle.net/1993/35337 | |
| dc.language.rfc3066 | en | |
| dc.rights | open access | en_US |
| dc.rights.holder | The Author(s) | |
| dc.title | Effectiveness of C1-INH therapy in angiotensin converting enzyme inhibitor induced angioedema |