Validation and minimum important difference of the UCSD Shortness of Breath Questionnaire in fibrotic interstitial lung disease

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dc.contributor.authorChen, Tao
dc.contributor.authorTsai, Amy P. Y.
dc.contributor.authorHur, Seo A.
dc.contributor.authorWong, Alyson W.
dc.contributor.authorSadatsafavi, Mohsen
dc.contributor.authorFisher, Jolene H.
dc.contributor.authorJohannson, Kerri A.
dc.contributor.authorAssayag, Deborah
dc.contributor.authorMorisset, Julie
dc.contributor.authorShapera, Shane
dc.contributor.authorKhalil, Nasreen
dc.contributor.authorFell, Charlene D.
dc.contributor.authorManganas, Helene
dc.contributor.authorCox, Gerard
dc.contributor.authorTo, Teresa
dc.contributor.authorGershon, Andrea S.
dc.contributor.authorHambly, Nathan
dc.contributor.authorHalayko, Andrew J.
dc.contributor.authorWilcox, Pearce G.
dc.contributor.authorKolb, Martin
dc.contributor.authorRyerson, Christopher J.
dc.date.accessioned2021-08-01T03:17:45Z
dc.date.issued2021-07-08
dc.date.updated2021-08-01T03:17:45Z
dc.description.abstractAbstract Rationale The University of California, San Diego Shortness of Breath Questionnaire (UCSDSOBQ) is a frequently used domain-specific dyspnea questionnaire; however, there is little information available regarding its use and minimum important difference (MID) in fibrotic interstitial lung disease (ILD). We aimed to describe the key performance characteristics of the UCSDSOBQ in this population. Methods UCSDSOBQ scores and selected anchors were measured in 1933 patients from the prospective multi-center Canadian Registry for Pulmonary Fibrosis. Anchors included the St. George’s Respiratory Questionnaire (SGRQ), European Quality of Life 5 Dimensions 5 Levels questionnaire (EQ-5D-5L) and EQ visual analogue scale (EQ-VAS), percent-predicted forced vital capacity (FVC%), diffusing capacity of the lung for carbon monoxide (DLCO%), and 6-min walk distance (6MWD). Concurrent validity, internal consistency, ceiling and floor effects, and responsiveness were assessed, followed by estimation of the MID by anchor-based (linear regression) and distribution-based methods (standard error of measurement). Results The UCSDSOBQ had a high level of internal consistency (Cronbach’s alpha = 0.97), no obvious floor or ceiling effect, strong correlations with SGRQ, EQ-5D-5L, and EQ-VAS (|r| > 0.5), and moderate correlations with FVC%, DLCO%, and 6MWD (0.3 < |r| < 0.5). The MID estimate for UCSDSOBQ was 5 points (1–8) for the anchor-based method, and 4.5 points for the distribution-based method. Conclusion This study demonstrates the validity of UCSDSOBQ in a large and heterogeneous population of patients with fibrotic ILD, and provides a robust MID estimate of 5–8 points.
dc.identifier.citationRespiratory Research. 2021 Jul 08;22(1):202
dc.identifier.urihttps://doi.org/10.1186/s12931-021-01790-0
dc.identifier.urihttp://hdl.handle.net/1993/35769
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderThe Author(s)
dc.titleValidation and minimum important difference of the UCSD Shortness of Breath Questionnaire in fibrotic interstitial lung disease
dc.typeJournal Article
local.author.affiliationRady Faculty of Health Sciencesen_US
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