Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass

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dc.contributor.authorChoi, Nora
dc.contributor.examiningcommitteeHayGlass, Kent (Immunology) Wilkins, John (Internal Medicine) Rigatto, Claudio (Internal Medicine)en_US
dc.contributor.supervisorHo, Julie (Immunology)en_US
dc.date.accessioned2018-01-10T14:59:14Z
dc.date.available2018-01-10T14:59:14Z
dc.date.issued2017en_US
dc.degree.disciplineImmunologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractCurrently, there are no successful therapies proven to ameliorate acute kidney injury (AKI). AKI secondary to ischemia reperfusion injury (IRI) leads to increased morbidity and mortality. The role of iron sequestration throughout cardiac surgery remains unclear, however it may be an important modifier of renal ischemia reperfusion injury. The primary goal was to characterize iron regulatory pathways in a prospective observational cohort of adult cardiac surgery patients in the context of clinical AKI predictors and in relation to clinical prediction alone. The secondary goal was to evaluate potential proteins that may act as non-invasive biomarkers for the early detection of AKI, including urine hepcidin-25, serum ferritin, serum transferrin saturation (TSAT) and urine lactotransferrin. We found that urine hepcidin-25 at postoperative day 1 and serum ferritin and TSAT at 1 hour into cardiopulmonary bypass were independent predictors of AKI avoidance on multivariate analysis, enhancing clinical prediction alone.en_US
dc.description.noteFebruary 2018en_US
dc.identifier.citationChoi N., Rigatto C., Zappitelli M.,… Ho J. (2017) Urinary Hepcidin-25 Is Elevated in Patients that Avoid Acute Kidney Injury Following Cardiac Surgery. Can J Kid Health Dis. Accepted 4 Aug 2017.en_US
dc.identifier.urihttp://hdl.handle.net/1993/32763
dc.language.isoengen_US
dc.publisherSAGEen_US
dc.rightsopen accessen_US
dc.subjectAcute kidney injuryen_US
dc.titleStudy of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypassen_US
dc.typemaster thesisen_US
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