dc.contributor.author	Rodd, Celia
dc.contributor.author	Metzger, Daniel L
dc.contributor.author	Sharma, Atul
dc.contributor.author	the Canadian Pediatric Endocrine Group (CPEG) Working Committee for National Growth Charts
dc.date.accessioned	2014-04-02T10:39:07Z
dc.date.available	2014-04-02T10:39:07Z
dc.date.issued	2014-02-03
dc.date.updated	2014-04-02T10:39:08Z
dc.description.abstract	Abstract Background For ages 5–19 years, the World Health Organization (WHO) publishes reference charts based on ‘core data’ from the US National Center for Health Statistics (NCHS), collected from 1963–75 on 22,917 US children. To promote the use of body mass index in older children, weight-for-age was omitted after age 10. Health providers have subsequently expressed concerns about this omission and the selection of centiles. We therefore sought to extend weight-for-age reference curves from 10 to 19 years by applying WHO exclusion criteria and curve fitting methods to the core NCHS data and to revise the choice of displayed centiles. Methods WHO analysts first excluded ~ 3% of their reference population in order to achieve a “non-obese sample with equal height”. Based on these exclusion criteria, 314 girls and 304 boys were first omitted for ‘unhealthy’ weights-for-height. By applying WHO global deviance and information criteria, optimal Box-Cox power exponential models were used to fit smoothed weight-for-age centiles. Bootstrap resampling was used to assess the precision of centile estimates. For all charts, additional centiles were included in the healthy range (3 to 97%), and the more extreme WHO centiles 0.1 and 99.9% were dropped. Results In addition to weight-for-age beyond 10 years, our charts provide more granularity in the centiles in the healthy range −2 to +2 SD (3–97%). For both weight and BMI, the bootstrap confidence intervals for the 99.9th centile were at least an order of magnitude wider than the corresponding 50th centile values. Conclusions These charts complement existing WHO charts by allowing weight-for-age to be plotted concurrently with height in older children. All modifications followed strict WHO methodology and utilized the same core data from the US NCHS. The additional centiles permit a more precise assessment of normal growth and earlier detection of aberrant growth as it crosses centiles. Elimination of extreme centiles reduces the risk of misclassification. A complete set of charts is available at the CPEG web site (http://cpeg-gcep.net).
dc.description.version	Peer Reviewed
dc.identifier.citation	BMC Pediatrics. 2014 Feb 03;14(1):32
dc.identifier.doi	http://dx.doi.org/10.1186/1471-2431-14-32
dc.identifier.uri	http://hdl.handle.net/1993/23355
dc.language.rfc3066	en
dc.rights	open access	en_US
dc.rights.holder	Celia Rodd et al.; licensee BioMed Central Ltd.
dc.title	Extending World Health Organization weight-for-age reference curves to older children
dc.type	Journal Article

Extending World Health Organization weight-for-age reference curves to older children

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