Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies

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dc.contributor.authorBanerji, Versha
dc.contributor.authorGibson, Spencer B.
dc.date.accessioned2015-05-14T16:18:52Z
dc.date.available2015-05-14T16:18:52Z
dc.date.issued2012-7-8
dc.date.updated2015-03-29T13:29:50Z
dc.description.abstractAutophagy is a cellular process that maintains the homeostasis of the normal cell. It not only allows for cell survival in times of metabolic stress with nutrient recycling but also is able to lead to cell death when required. During malignant transformation the cell is able to proliferate and survive. This is due to altered cell metabolism and the presence of altered genetic changes that maintain the cell survival. Metabolism was considered an innocent bystander that was a consequence of the increased nutrient requirement for the survival and proliferation of haematological malignancies. The interdependency of metabolism and cellular mechanisms such as autophagy are becoming more evident and important. This interdependence contributes to increased cancer progression and drug resistance. In this paper we aim to discuss autophagy, how it pertains to metabolism in the context of hematologic malignancies, and the implications for therapy.
dc.description.versionPeer Reviewed
dc.identifier.citationVersha Banerji and Spencer B. Gibson, “Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies,” International Journal of Cell Biology, vol. 2012, Article ID 595976, 9 pages, 2012. doi:10.1155/2012/595976
dc.identifier.urihttp://dx.doi.org/10.1155/2012/595976
dc.identifier.urihttp://hdl.handle.net/1993/30484
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2012 Versha Banerji and Spencer B. Gibson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleTargeting Metabolism and Autophagy in the Context of Haematologic Malignancies
dc.typeJournal Article
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