The Role of Voltage-Gated Sodium Channel 1.3 on Subfornical Organ Neurons

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dc.contributor.authorHuang, Shuo
dc.contributor.examiningcommitteeTreberg, Jason (Biological Sciences) Aukema, Harold (Human Nutritional Sciences)en_US
dc.contributor.supervisorFry, Mark (Biological Sciences)en_US
dc.date.accessioned2014-10-09T13:29:21Z
dc.date.available2014-10-09T13:29:21Z
dc.date.issued2014-10-09
dc.degree.disciplineBiological Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractThe subfornical organ (SFO) is an area in the brain characterized by lack of a blood-brain-barrier that contributes to interaction between the circulation and the central nervous system, and plays key roles in regulation of energy balance. The SFO has two subregions- the dorsolateral peripheral SFO (pSFO) and the ventromedial core of the SFO (cSFO). This study demonstrated the expression of voltage-gated Na+ channel 1.3 (Nav1.3) in the SFO neurons, and a higher Nav1.3 expression in the pSFO. Based on the Nav1.3 expression pattern, intrinsic electrophysiological properties were compared between cSFO and non-cSFO neurons (putative pSFO neurons) identified by a SmartFlare mRNA probe. The patch clamp results revealed a bursting firing pattern in cSFO neurons and a higher spontaneous neuronal activity in non-cSFO neurons. The higher neuronal activity might be related to a more depolarized resting membrane potential and a higher trend of Na+ current density.en_US
dc.description.noteFebruary 2015en_US
dc.identifier.urihttp://hdl.handle.net/1993/24091
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectSubfornical organen_US
dc.subjectNav1.3en_US
dc.subjectEnergy balanceen_US
dc.subjectElectrophysiologyen_US
dc.titleThe Role of Voltage-Gated Sodium Channel 1.3 on Subfornical Organ Neuronsen_US
dc.typemaster thesisen_US
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