The effects of carrot carotenoids on diabetic retinopathy in Type 1 diabetes mellitus

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dc.contributor.authorMcClinton, Kathleen
dc.contributor.examiningcommitteeAliani, Michel (Human Nutritional Sciences) Sauve, Yves (Ophthalmology, University of Alberta)en_US
dc.contributor.supervisorSuh, Miyoung (Human Nutritional Sciences)en_US
dc.date.accessioned2012-09-14T21:49:05Z
dc.date.available2012-09-14T21:49:05Z
dc.date.issued2012-09-14
dc.degree.disciplineHuman Nutritional Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractWhile carotenoids are essential for visual function, their potential role in diabetic retinopathy is not known. By providing carrot powder, this study examined carotenoid metabolism and visual function in Type 1 diabetes. Wistar rats (n=30) were assigned to diet either with or without carrot enrichment (15%, w/w) for 12 weeks. Type 1 diabetes was induced with streptozotocin at 3 weeks. Retinal function and anatomical integrity were assessed along with retinoid and carotenoid levels in the serum, liver, and retina. Loss of ERG oscillatory potentials, with normal histology indicated early stage retinopathy. Healthy animals fed carrot diet showed highest b-wave amplitudes; reflecting higher phototransduction. Diabetic animals fed carrot diet had the lowest b-wave amplitudes, reduced retinoids liver reserves, and highest α- and β-carotene, suggesting disturbance of conversion during diabetes. Consequently carrot powder at concentrations used by this study cannot be recommended for diabetic retinopathy.en_US
dc.description.noteOctober 2012en_US
dc.identifier.urihttp://hdl.handle.net/1993/8862
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjecttype 1 diabetesen_US
dc.subjectcarotenoidsen_US
dc.subjectretinoidsen_US
dc.subjectretinopathyen_US
dc.subjectnutritionen_US
dc.subjectUPLCen_US
dc.titleThe effects of carrot carotenoids on diabetic retinopathy in Type 1 diabetes mellitusen_US
dc.typemaster thesisen_US
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