Inhibitory Properties of Aqueous Ethanol Extracts of Propolis on Alpha-Glucosidase

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dc.contributor.authorZhang, Hongcheng
dc.contributor.authorWang, Guangxin
dc.contributor.authorBeta, Trust
dc.contributor.authorDong, Jie
dc.date.accessioned2015-05-14T15:47:21Z
dc.date.available2015-05-14T15:47:21Z
dc.date.issued2015-2-12
dc.date.updated2015-03-29T12:42:52Z
dc.description.abstractThe objective of the present study was to evaluate the inhibitory properties of various extracts of propolis on alpha-glucosidase from baker’s yeast and mammalian intestine. Inhibitory activities of aqueous ethanol extracts of propolis were determined by using 4-nitrophenyl-D-glucopyranoside, sucrose and maltose as substrates, and acarbose as a positive reference. All extracts were significantly effective in inhibiting α-glucosidase from baker’s yeast and rat intestinal sucrase in comparison with acarbose (). The 75% ethanol extracts of propolis (75% EEP) showed the highest inhibitory effect on α-glucosidase and sucrase and were a noncompetitive inhibition mode. 50% EEP, 95%, EEP and 100% EEP exhibited a mixed inhibition mode, while water extracts of propolis (WEP) and 25% EEP demonstrated a competitive inhibition mode. Furthermore, WEP presented the highest inhibitory activity against maltase. These results suggest that aqueous ethanol extracts of propolis may be used as nutraceuticals for the regulation of postprandial hyperglycemia.
dc.description.versionPeer Reviewed
dc.identifier.citationHongcheng Zhang, Guangxin Wang, Trust Beta, and Jie Dong, “Inhibitory Properties of Aqueous Ethanol Extracts of Propolis on Alpha-Glucosidase,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 587383, 7 pages, 2015. doi:10.1155/2015/587383
dc.identifier.urihttp://dx.doi.org/10.1155/2015/587383
dc.identifier.urihttp://hdl.handle.net/1993/30455
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2015 Hongcheng Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleInhibitory Properties of Aqueous Ethanol Extracts of Propolis on Alpha-Glucosidase
dc.typeJournal Article
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