Ghrelin: Central Nervous System Sites of Action in Regulation of Energy Balance

Simple item page
dc.contributor.authorFry, Mark
dc.contributor.authorFerguson, Alastair V.
dc.date.accessioned2015-04-01T17:26:12Z
dc.date.available2015-04-01T17:26:12Z
dc.date.issued2010-2-15
dc.date.updated2015-03-29T13:39:34Z
dc.description.abstractGhrelin, a peptide hormone secreted by the stomach, has been shown to regulate energy homeostasis by modulating electrical activity of neurons in the central nervous system (CNS). Like many circulating satiety signals, ghrelin is a peptide hormone and is unable to cross the blood-brain barrier without a transport mechanism. In this review, we address the notion that the arcuate nucleus of the hypothalamus is the only site in the CNS that detects circulating ghrelin to trigger orexigenic responses. We consider the roles of a specialized group of CNS structures called the sensory circumventricular organs (CVOs), which are not protected by the blood-brain barrier. These areas include the subfornical organ and the area postrema and are already well known to be key areas for detection of other circulating hormones such as angiotensin II, cholecystokinin, and amylin. A growing body of evidence indicates a key role for the sensory CVOs in the regulation of energy homeostasis.
dc.description.versionPeer Reviewed
dc.identifier.citationMark Fry and Alastair V. Ferguson, “Ghrelin: Central Nervous System Sites of Action in Regulation of Energy Balance,” International Journal of Peptides, vol. 2010, Article ID 616757, 8 pages, 2010. doi:10.1155/2010/616757
dc.identifier.urihttp://dx.doi.org/10.1155/2010/616757
dc.identifier.urihttp://hdl.handle.net/1993/30328
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2010 Mark Fry and Alastair V. Ferguson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleGhrelin: Central Nervous System Sites of Action in Regulation of Energy Balance
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
IJPEP.2010.616757.xml
Size:
6.08 KB
Format:
Extensible Markup Language
Description:
Download
Thumbnail Image
Name:
IJPEP.2010.616757.pdf
Size:
1.29 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.27 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
University of Manitoba Scholarship
Faculty of Science Scholarly Works