Do propriospinal neurons contribute to transmission of the locomotor command signal in adult mammals?

Simple item page
dc.contributor.authorAnsari, Jahanzeb
dc.contributor.examiningcommitteeCowley, Kristine (Physiology and Pathophysiology) MacNeil, Brian (Physical Therapy)en_US
dc.contributor.supervisorSchmidt, Brian (Physiology and Pathophysiology) Stecina, Katinka (Physiology and Pathophysiology)en_US
dc.date.accessioned2016-09-20T16:40:04Z
dc.date.available2016-09-20T16:40:04Z
dc.date.issued2016
dc.degree.disciplinePhysiology and Pathophysiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractLong projections from the brainstem to the lumbar cord activate locomotion. Using in vitro neonatal rats our laboratory showed that relay (propriospinal - PS) neurons also contribute to transmission of the locomotor signal. This thesis examines whether locomotor-related PS neurons exist in adult mammals, which has important clinical implications. The brainstem of adult decerebrate rats was stimulated to elicit stepping. The following manipulations were performed: 1) suppression of synaptic transmission to PS neurons, 2) lesioning of direct bulbospinal projections to lumbar segments, and 3) neurochemical excitation of PS neurons. In addition, in the absence of brainstem stimulation, the ability of neurochemically excited PS neurons to induce stepping was examined. Brainstem-evoked locomotion was suppressed by synaptic blockade, enhanced by PS neuron excitation, persists after lesioning of long-direct projections, and hindlimb stepping was elicited by PS neuron excitation alone. The findings support the existence of a locomotor-related PS system in adult mammals.en_US
dc.description.noteOctober 2016en_US
dc.identifier.urihttp://hdl.handle.net/1993/31826
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectLocomotionen_US
dc.subjectPropriospinalen_US
dc.subjectSpinal corden_US
dc.subjectHemisectionen_US
dc.titleDo propriospinal neurons contribute to transmission of the locomotor command signal in adult mammals?en_US
dc.typemaster thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Thesis J Ansari-revised.pdf
Size:
2.22 MB
Format:
Adobe Portable Document Format
Description:
Complete M.Sc thesis - Jahanzeb Ansari # 7777742
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.2 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
FGS - Electronic Theses and Practica