Epidemiology of Neuromyelitis Optica in the World: A Systematic Review and Meta-Analysis

Simple item page
dc.contributor.authorEtemadifar, Masoud
dc.contributor.authorNasr, Zahra
dc.contributor.authorKhalili, Behrang
dc.contributor.authorTaherioun, Maryam
dc.contributor.authorVosoughi, Reza
dc.date.accessioned2015-05-14T15:34:08Z
dc.date.available2015-05-14T15:34:08Z
dc.date.issued2015-4-20
dc.date.updated2015-04-20T13:53:46Z
dc.description.abstractBackground. Neuromyelitis optica (Devic’s disease) is a severe autoimmune inflammatory disorder of the central nervous system. Epidemiological aspects of NMO have not been systemically reviewed. In this study we systematically reviewed and assessed the quality of studies reporting the incidence and/or prevalence of NMO across the world. Methods. A comprehensive literature search using MEDLINE, EMBASE, and Web of Science for the terms “Neuromyelitis optica,” “devic disease,” “incidence,” “prevalence,” and “epidemiology” was conducted on January 31, 2015. Study quality was assessed using an assessment tool based on recognized guidelines and designed specifically for this study. Results. A total of 216 studies were initially identified, with only 9 meeting the inclusion criteria. High level of heterogeneity amongst studies precluded a firm conclusion. Incidence data were found in four studies and ranged from 0.053 per 100,000 per year in Cuba to 0.4 in Southern Denmark. Prevalence was reported in all studies and ranged from 0.51 per 100,000 in Cuba to 4.4 in Southern Denmark. Conclusion. This review reveals the gaps that still exist in the epidemiological knowledge of NMO in the world. Published studies have different qualities and methodology precluding a robust conclusion. Future researches focusing on epidemiological features of NMO in different nations and different ethnic groups are needed.
dc.description.versionPeer Reviewed
dc.identifier.citationMasoud Etemadifar, Zahra Nasr, Behrang Khalili, Maryam Taherioun, and Reza Vosoughi, “Epidemiology of Neuromyelitis Optica in the World: A Systematic Review and Meta-Analysis,” Multiple Sclerosis International, vol. 2015, Article ID 174720, 8 pages, 2015. doi:10.1155/2015/174720
dc.identifier.urihttp://dx.doi.org/10.1155/2015/174720
dc.identifier.urihttp://hdl.handle.net/1993/30447
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2015 Masoud Etemadifar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleEpidemiology of Neuromyelitis Optica in the World: A Systematic Review and Meta-Analysis
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
MSI.2015.174720.xml
Size:
7.23 KB
Format:
Extensible Markup Language
Description:
Download
Thumbnail Image
Name:
MSI.2015.174720.pdf
Size:
731.47 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.27 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
University of Manitoba Scholarship
Rady Faculty of Health Sciences Scholarly Works