Genomic and phylogenetic assessment of sea lamprey (Petromyzon marinus) Hox genes and analysis of Hox genes in association with myomeres across multiple lamprey genera

Simple item page
dc.contributor.authorChilds, Darcy
dc.contributor.examiningcommitteeBelmonte, Mark (Biological Sciences) Rastegar, Mojgan (Biochemistry & Medical Genetics)en_US
dc.contributor.supervisorWhyard, Steve (Biological Sciences) Docker, Margaret (Biological Sciences)en_US
dc.date.accessioned2013-08-22T13:48:13Z
dc.date.available2013-08-22T13:48:13Z
dc.date.issued2013-08-22
dc.degree.disciplineBiological Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractLampreys are an important model for the study of early vertebrate development due to their unique evolutionary position as one of only two extant jawless vertebrates. In this study, 12 new putative Hox gene fragments were identified within the recently available Petromyzon marinus (sea lamprey) genome. These and the other previously-identified Hox genes were analyzed phylogenetically, which enabled the assignment of many of the new sequences to distinct paralogous gene clusters and showed distinctions between gnathostome and lamprey Hox sequences. An examination of Hox genes in other lamprey species was conducted using genomic PCR-based detection methods and identified 26 putative Hox gene homeobox fragments from multiple Hox genes across nine lamprey species. A study of Hox10 coding sequences in different lamprey species failed to find any correlation with variable numbers of trunk myomeres in lampreys, which suggests that other sequences or factors regulate the number of myomeres in different species.en_US
dc.description.noteOctober 2013en_US
dc.identifier.urihttp://hdl.handle.net/1993/22058
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectMolecularen_US
dc.subjectLampreyen_US
dc.subjectBioinformaticsen_US
dc.subjectPhylogeneticsen_US
dc.subjectHoxen_US
dc.titleGenomic and phylogenetic assessment of sea lamprey (Petromyzon marinus) Hox genes and analysis of Hox genes in association with myomeres across multiple lamprey generaen_US
dc.typemaster thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Childs_Darcy.pdf
Size:
5.99 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.25 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
FGS - Electronic Theses and Practica