The synovial proteome: analysis of fibroblast-like synoviocytes

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dc.contributor.authorDasuri, Kumar
dc.contributor.authorAntonovici, Mihaela
dc.contributor.authorChen, Keding
dc.contributor.authorWong, Ken
dc.contributor.authorStanding, Kenneth
dc.contributor.authorEns, Werner
dc.contributor.authorEl-Gabalawy, Hani
dc.contributor.authorWilkins, John A
dc.date.accessioned2015-11-16T18:15:22Z
dc.date.available2015-11-16T18:15:22Z
dc.date.issued2004-02-16
dc.date.updated2015-11-14T07:03:07Z
dc.description.abstractAbstract The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by matrix-assisted laser desorption ionization mass spectrometry. A total of 368 spots were examined and 254 identifications were made. The studies identified a number of proteins that have been implicated in the normal or pathological FLS function (e.g. uridine diphosphoglucose dehydrogenase, galectin 1 and galectin 3) or that have been characterized as potential autoantigens in rheumatoid arthritis (e.g. BiP, colligin, HC gp-39). A novel uncharacterized protein product of chromosome 19 open reading frame 10 was also detected as an apparently major component of FLS cells. These results demonstrate the utility of high-content proteomic approaches in the analysis of FLS composition.
dc.identifier.citationArthritis Res Ther. 2004 Feb 16;6(2):R161
dc.identifier.urihttp://dx.doi.org/10.1186/ar1153
dc.identifier.urihttp://hdl.handle.net/1993/30934
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderDasuri et al.
dc.titleThe synovial proteome: analysis of fibroblast-like synoviocytes
dc.typeJournal Article
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