Intrathecal interleukin-6 levels are associated with progressive disease and clinical severity in multiple sclerosis

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dc.contributor.authorItorralba, Justine
dc.contributor.authorBrand-Arzamendi, Koroboshka
dc.contributor.authorSaab, Georges
dc.contributor.authorMuccilli, Alexandra
dc.contributor.authorSchneider, Raphael
dc.date.accessioned2025-05-01T19:06:49Z
dc.date.available2025-05-01T19:06:49Z
dc.date.issued2025-04-02
dc.date.updated2025-05-01T03:36:44Z
dc.description.abstractAbstract Background MS is characterized by persistent central nervous system (CNS) inflammation. Investigating the CNS-compartmentalized inflammation associated with progressive MS could uncover new biomarkers and therapeutic targets. Cerebrospinal fluid (CSF) interleukin-6 (IL-6) can be markedly elevated in neuroinflammatory conditions, such as neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease. This study investigated the association between CSF IL-6 levels, progressive disease, and disease severity in MS. Methods Advanced technologies, including single-molecule arrays and microfluidics, were used to analyse CSF samples from individuals with MS at the time of diagnosis for IL-6. IL-6 levels were then correlated with clinical course, disease severity, and other known biomarkers associated with inflammation and disease severity. Results Elevated IL-6 levels in the CSF were found in individuals with progressive MS, and CSF IL-6 showed positive correlations with the Expanded Disability Status Scale, the Multiple Sclerosis Severity Score, and CSF glial fibrillary acidic protein levels. Conclusions IL-6 in CSF indicates ongoing CNS inflammation and may contribute to the compartmentalized inflammation associated with disease progression and overall disease severity.
dc.identifier.citationBMC Neurology. 2025 Apr 02;25(1):136
dc.identifier.doi10.1186/s12883-025-04145-0
dc.identifier.urihttp://hdl.handle.net/1993/39057
dc.language.isoeng
dc.language.rfc3066en
dc.publisherBMC
dc.rights.holderThe Author(s)
dc.subjectMultiple sclerosis
dc.subjectInterleukin-6
dc.subjectCerebrospinal fluid
dc.subjectDisease progression
dc.subjectNeuroinflammation
dc.titleIntrathecal interleukin-6 levels are associated with progressive disease and clinical severity in multiple sclerosis
dc.typeresearch article
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Internal Medicine
oaire.citation.startPage136
oaire.citation.titleBMC Neurology
oaire.citation.volume25
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