The innate immune system utilizes an intricate network to aid in fighting foreign invaders. Recent insight and understanding of toll-like receptors (TLRs) has been critical in providing key information about early responses to infection, and more recently, understanding dysregulation of TLRs has shed light on pathogenic states. This paper addresses the importance of innate immunity and TLR regulation of immune responses to the presence of influenza infection and its role in the subsequent bacterial infections.