Mortality risk for women on chronic hemodialysis differs by age

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dc.contributor.authorSood, Manish M
dc.contributor.authorRigatto, Claudio
dc.contributor.authorKomenda, Paul
dc.contributor.authorMojica, Julie
dc.contributor.authorTangri, Navdeep
dc.date.accessioned2014-06-24T11:14:35Z
dc.date.available2014-06-24T11:14:35Z
dc.date.issued2014-06-03
dc.date.updated2014-06-24T11:14:36Z
dc.description.abstractAbstract Background Previous reports have demonstrated similar survival for men and women on hemodialysis, despite women’s increased survival in the general population. Objectives To examine the effect of age on mortality in women undergoing chronic hemodialysis. Design A retrospective cohort study using an administrative data registry, the Canadian Organ Replacement Registry (CORR) from Jan. 2001 and Dec. 2009. Setting Canada. Patients 28,971 (Women 11,792 (40.7%), Men 17,179 (59.3%)) incident chronic hemodialysis patients who survived greater than 90 days on dialysis. Measurements All-cause mortality. Methods Cox proportional hazards and competing risks models were employed to determine the independent association between sex, age and likelihood of all-cause mortality with renal transplantation as the competing outcome. Results During the study period, 6060 (51.4%) of women and 8650 (50.4%) of men initiating dialysis died. Younger women experienced higher mortality (Age < 45: Women 22.5%, Men 18.2%, hazard ratio (HR) 1.31 (1.12-1.52)) whereas elderly women experience lower mortality (Age 75–85: Women 65%, Men 67.3%, HR 0.94 95% CI 0.88-0.99, Age > 85: Women 66%, Men 70.2%, HR 0.83 95% CI 0.71-0.97) compared to men. This relationship persisted after accounting for the competing risk of transplantation. Limitations The cause of death was unknown. Conclusions Women’s survival on chronic hemodialysis varies by age compared to men with a significantly higher mortality in women younger than 45 years old and lower mortality in woman older than 75 years of age.
dc.description.versionPeer Reviewed
dc.identifier.citationCanadian Journal of Kidney Health and Disease. 2014 Jun 03;1(1):10
dc.identifier.doihttp://dx.doi.org/10.1186/2054-3581-1-10
dc.identifier.urihttp://hdl.handle.net/1993/23643
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderManish M Sood et al.; licensee BioMed Central Ltd.
dc.titleMortality risk for women on chronic hemodialysis differs by age
dc.typeJournal Article
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