Early Use of the NMDA Receptor Antagonist Ketamine in Refractory and Superrefractory Status Epilepticus

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dc.contributor.authorZeiler, F. A.
dc.date.accessioned2015-05-14T15:59:30Z
dc.date.available2015-05-14T15:59:30Z
dc.date.issued2015-1-12
dc.date.updated2015-03-29T13:19:48Z
dc.description.abstractRefractory status epilepticus (RSE) and superrefractory status epilepticus (SRSE) pose a difficult clinical challenge. Multiple cerebral receptor and transporter changes occur with prolonged status epilepticus leading to pharmacoresistance patterns unfavorable for conventional antiepileptics. In particular, n-methyl-d-aspartate (NMDA) receptor upregulation leads to glutamate mediated excitotoxicity. Targeting these NMDA receptors may provide a novel approach to otherwise refractory seizures. Ketamine has been utilized in RSE. Recent systematic review indicates 56.5% and 63.5% cessation in seizures in adults and pediatrics, respectively. No complications were described. We should consider earlier implementation of ketamine or other NMDA receptor antagonists, for RSE. Prospective study of early implementation of ketamine should shed light on the role of such medications in RSE.
dc.description.versionPeer Reviewed
dc.identifier.citationF. A. Zeiler, “Early Use of the NMDA Receptor Antagonist Ketamine in Refractory and Superrefractory Status Epilepticus,” Critical Care Research and Practice, vol. 2015, Article ID 831260, 5 pages, 2015. doi:10.1155/2015/831260
dc.identifier.urihttp://dx.doi.org/10.1155/2015/831260
dc.identifier.urihttp://hdl.handle.net/1993/30461
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2015 F. A. Zeiler. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleEarly Use of the NMDA Receptor Antagonist Ketamine in Refractory and Superrefractory Status Epilepticus
dc.typeJournal Article
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