Impact of acute SCD1 inhibition on plasma lipids and its effect on nutrient handling and insulin signaling in murine skeletal muscle

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dc.contributor.authorOmar, Jaclyn M
dc.contributor.examiningcommitteeSuh, Miyoung (Human Nutritional Sciences) McGavock, Jon (Medicine)en_US
dc.contributor.supervisorHarding, Scott V (Human Nutritional Sciences) Jones, Peter (Human Nutritional Sciences)en_US
dc.date.accessioned2012-08-21T15:38:01Z
dc.date.available2012-08-21T15:38:01Z
dc.date.issued2012-08-21
dc.degree.disciplineHuman Nutritional Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractStearoyl-coA desaturase-1 (SCD1) activity has been linked to the development of obesity and the metabolic syndrome (MetS) through its central role in lipid metabolism. Understanding how changes in SCD1 activity affect obesity and MetS risk biomarkers and investigating how these changes in activity affect nutrient handling in non-hepatic tissues is also important. This study investigated how acute SCD1 inhibition effected plasma lipids, skeletal muscle nutrient handling and insulin signaling in mice fed a high-carbohydrate very-low fat diet for 10 weeks. This study demonstrated that SCD1 inhibition created acute dyslipidemia, altered nutrient handling protein activity and increased the percentage of saturated fatty acids (SFA) in hepatic and muscle tissue, independent of dietary oleic acid content. However, the molecular controls of protein synthesis in the mTOR pathway were not affected by the loss of SCD1 activity. In conclusion, we observed that inhibiting hepatic SCD1 activity and subsequently changing the monounsaturated fatty acid (MUFA) to SFA ratios in tissues alters normal nutrient handling in skeletal muscle.en_US
dc.description.noteOctober 2012en_US
dc.identifier.urihttp://hdl.handle.net/1993/8446
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectobesityen_US
dc.subjectde novo lipogenesisen_US
dc.subjectstearoyl co-a desaturase 1en_US
dc.subjectnutrient handlingen_US
dc.subjectprotein translationen_US
dc.subjectlipid metabolismen_US
dc.titleImpact of acute SCD1 inhibition on plasma lipids and its effect on nutrient handling and insulin signaling in murine skeletal muscleen_US
dc.typemaster thesisen_US
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