Polyurethane (PU)-derived photoactive and copper-free clickable surface based on perfluorophenyl azide (PFPA) chemistry

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dc.contributor.authorLiu, Song
dc.contributor.authorLi, Lingdong
dc.contributor.authorLi, Jiang
dc.contributor.authorKulkarni, Abhilash
dc.date.accessioned2018-10-05T15:01:16Z
dc.date.available2018-10-05T15:01:16Z
dc.date.issued2013-01
dc.date.submitted2018-10-04T03:52:27Zen
dc.description.abstractThe anchoring and capturing roles of perfluorophenyl azide (PFPA) were combined to produce a universal polyurethane (PU)-derived photoactive surface platform (PU-1-PFPA). The resultant platform was confirmed by contact angle, attenuated total reflectance Fourier transform infrared (ATR FT-IR) spectroscopy, atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS) analyses. Upon UV light activation, native heparin was coupled directly onto PU-1-PFPA to yield a substrate with antithrombogenic properties. The same level of antithrombogenic activity was achieved when the recovered heparin was photo-coupled onto PU-1-PFPA. In addition, at room temperature and in the absence of copper catalysts, PU-1-PFPA achieved oriented immobilization of functional moieties bearing an alkynyl functional group.en_US
dc.description.sponsorshipThis work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant (Grant no: RGPIN/372048-2009), the Manitoba Health Research Council (MHRC) Establishment grant, and Collaborative Health Research Projects (CHRP) operating grant (Grant no: CHRP 413713-2012).en_US
dc.identifier.citationLi, L.; Li, J.; Kulkarni, A.; Liu, S.* Polyurethane (PU)-derived photoactive and copper-free clickable surface based on perfluorophenyl azide (PFPA) chemistry. J. Mater. Chem. B, 2013,1, 571-582en_US
dc.identifier.doi10.1039/C2TB00248E
dc.identifier.urihttp://hdl.handle.net/1993/33524
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsopen accessen_US
dc.subjectphotoactive and copper-free click reactionen_US
dc.subjectperfluorophenyl azide chemistryen_US
dc.titlePolyurethane (PU)-derived photoactive and copper-free clickable surface based on perfluorophenyl azide (PFPA) chemistryen_US
dc.typeArticleen_US
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