Effect of α-lactalbumin and β-lactoglobulin hydrolysates on markers of metabolic syndrome

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dc.contributor.authorLagace, Melissa
dc.contributor.examiningcommitteeScanlon, Martin (Food Science) Aluko, Rotimi (Human Nutritional Sciences)en_US
dc.contributor.supervisorArntfield, Susan (Food Science) Rempel, Curtis (Food Science)en_US
dc.date.accessioned2012-09-07T14:32:17Z
dc.date.available2012-09-07T14:32:17Z
dc.date.issued2012-09-07
dc.degree.disciplineFood Scienceen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractThe effects of peptides derived from β-lactoglobulin and α-lactalbumin on metabolic syndrome were studied. α-lactalbumin and β-lactoglobulin were hydrolyzed with trypsin, alcalase, flavourzyme, or a combination of alcalase and flavourzyme and fractionated. Angiotensin coverting enzyme inhibition of the < 1 kDa fraction of alcalase hydrolyzed β-lactoglobulin was 95 %. Antioxidant activity of the < 1 kDa fraction of β-lactoglobulin hydrolyzed with a combination of alcalase and flavourzyme was 18 %. Stimulated adipocytes incubated with the < 1 kDa fraction of β-lactoglobulin hydrolyzed with either trypsin or alcalase produced 30 pg/mL of interleukin 6. Adiponectin and glucose transporter type 4 secretions increased 1.1 and 0.86 fold respectively during incubation with the < 1 kDa fraction of β-lactoglobulin hydrolyzed with a combination of alcalase and flavourzyme. Results indicate that β-lactoglobulin peptides formed with alcalase and a combination of alcalase and flavourzyme influence markers associated with metabolic syndrome and may be useful as functional foods or nutraceuticals.en_US
dc.description.noteOctober 2012en_US
dc.identifier.urihttp://hdl.handle.net/1993/8617
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectmetabolicen_US
dc.subjectwheyen_US
dc.subjectinflammationen_US
dc.subjecthypertensionen_US
dc.subjectdiabetesen_US
dc.subjecthydrolysisen_US
dc.subjectsyndromeen_US
dc.subjectlactalbuminen_US
dc.subjectlactoglobulinen_US
dc.subjectinterleukinen_US
dc.subjectadipocyteen_US
dc.subjectmacrophageen_US
dc.subjectglucoseen_US
dc.subjectadiponectinen_US
dc.subjectalcalaseen_US
dc.subjectflavourzymeen_US
dc.subjecttrypsinen_US
dc.subjectoryzaeen_US
dc.subjectlichenformisen_US
dc.subjectpeptideen_US
dc.titleEffect of α-lactalbumin and β-lactoglobulin hydrolysates on markers of metabolic syndromeen_US
dc.typemaster thesisen_US
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