Rational approach towards the design of netrin- 1/UNC5 and netrin-1/DCC interaction inhibitors
| dc.contributor.author | Wang, Guanyu | |
| dc.contributor.examiningcommittee | Stetefeld, Jörg (Chemistry) Cardona, Silvia (Microbiology) | en_US |
| dc.contributor.supervisor | Davis, Rebecca (Chemistry) | en_US |
| dc.date.accessioned | 2019-05-27T15:54:58Z | |
| dc.date.available | 2019-05-27T15:54:58Z | |
| dc.date.issued | 2019-04-25 | en_US |
| dc.date.submitted | 2019-04-26T04:39:37Z | en |
| dc.degree.discipline | Chemistry | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | This study mainly focuses on the rational design, synthesis and bioassay testing of netrin-1/UNC5 and netrin-1/DCC inhibitors. This study began with the development of a virtual screening method to select out candidates from virtual libraries. These candidates were then synthesized and the binding affinity between the synthesized molecules and netrin-1 was evaluated by microscale thermophoresis. | en_US |
| dc.description.note | October 2019 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/33912 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | netrin-1 | en_US |
| dc.subject | DCC | en_US |
| dc.subject | UNC5 | en_US |
| dc.subject | Rational Design | en_US |
| dc.subject | Drug Design | en_US |
| dc.title | Rational approach towards the design of netrin- 1/UNC5 and netrin-1/DCC interaction inhibitors | en_US |
| dc.type | master thesis | en_US |