Localization of serotonergic neurons in the Parapyramidal Region in the mouse activated during locomotion on a treadmill using c-fos as a neuronal activity marker

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dc.contributor.authorCouto Roldan, Erika
dc.contributor.examiningcommitteeMcCrea, David (Physiology and Pathophysiology) Fedirchuk, Brent (Physiology and Pathophysiology) Gardiner, Phillip (Kinesiology and Recreation Management)en_US
dc.contributor.supervisorJordan, Larry (Physiology and Pathophysiology)en_US
dc.date.accessioned2015-01-19T21:14:35Z
dc.date.available2015-01-19T21:14:35Z
dc.date.issued2015-01-19
dc.degree.disciplinePhysiology and Pathophysiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractWe studied the expression of c-fos in medullary serotonergic neurons after a locomotor task on a treadmill in adult mice. We used a transgenically modified line in which serotonergic cells expressed enhanced yellow fluorescent protein (eYFP). We counted and plotted cells using Micro Bright Field Co. software. We determined the location of the serotonergic cells in this mouse line in the adult. We found an increase in the number of eYFP-positive cells expressing c-fos after a locomotor task in the raphe and PPR between bregma -6.8 and bregma -6.48 in the mouse (flanked rostrally by the seventh cranial nerve and caudally by the inferior olive). The percentage of eYFP-positive cells that expressed c-fos after the locomotor task in the raphe was 4%, whereas in the PPR the percentage was13.3%. Our results corroborate the observation that a specific group of serotonergic neurons located in the PPR are involved in locomotion.en_US
dc.description.noteFebruary 2015en_US
dc.identifier.urihttp://hdl.handle.net/1993/30235
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectLocomotionen_US
dc.subjectSerotoninen_US
dc.subjectc-fosen_US
dc.subjectParapyramidal Regionen_US
dc.titleLocalization of serotonergic neurons in the Parapyramidal Region in the mouse activated during locomotion on a treadmill using c-fos as a neuronal activity markeren_US
dc.typemaster thesisen_US
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