Scleraxis and transcription factor 15 expression in the failing myocardium

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dc.contributor.authorFilomeno, Krista
dc.contributor.examiningcommitteeKardami, Elissavet (Human Anatomy and Cell Science) Duhamel, Todd (Kinesiology and Recreation Management) Triggs-Raine, Barbara (Biochemistry and Medical Genetics)en_US
dc.contributor.supervisorDixon, Ian (Physiology and Pathophysiology) Czubryt, Michael (Physiology and Pathophysiology)en_US
dc.date.accessioned2018-04-16T20:48:44Z
dc.date.available2018-04-16T20:48:44Z
dc.date.issued2018
dc.date.submitted2018-03-26T19:06:49Zen
dc.date.submitted2018-04-13T17:46:50Zen
dc.degree.disciplinePhysiology and Pathophysiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractThere is still no specific treatment for fibrosis, a common co-morbidity to many cardiovascular diseases. We examined the association in expression of the pro-fibrotic protein scleraxis and its paralog transcription factor 15 (TCF15), with the myofibroblast marker α-smooth muscle actin (α-SMA), after myocardial infarction (MI) in an experimental model in vivo. Echocardiography revealed that the hearts of the post-infarct rats were in a state of systolic dysfunction across all time points. Left (infarcted scar and non-infarcted) and right cardiac ventricles from male Sprague-Dawley rats were obtained at 2-4 days and 1-8 weeks post-MI. Western blot analysis shows that scleraxis, TCF15 and α-SMA is all increased within the infarct scar in all stages of wound healing compared to sham-operated controls. Thus, scleraxis and TCF15 are co-expressed in the infarct scar of post-MI hearts. Using one of these proteins as a biological target for possible treatments may serve to limit cardiac fibrosis.en_US
dc.description.noteMay 2018en_US
dc.identifier.urihttp://hdl.handle.net/1993/32982
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectHeart Failureen_US
dc.subjectScleraxisen_US
dc.subjectTCF15en_US
dc.subjectTranscription Factor 15en_US
dc.subjectFibrosisen_US
dc.subjectMyocardial Infarctionen_US
dc.titleScleraxis and transcription factor 15 expression in the failing myocardiumen_US
dc.typemaster thesisen_US
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