Assessment of tissue oxygenation of periodontal inflammation in patients with coronary artery diseases using optical spectroscopy

Simple item page
dc.contributor.authorZhang, Chunyang
dc.contributor.authorXiang, Xiaoming
dc.contributor.authorXu, Minqi
dc.contributor.authorFan, Chun
dc.contributor.authorSowa, Michael G
dc.contributor.authorLiu, Kan-Zhi
dc.date.accessioned2014-04-22T03:33:06Z
dc.date.available2014-04-22T03:33:06Z
dc.date.issued2014-03-25
dc.date.updated2014-04-22T03:33:06Z
dc.description.abstractAbstract Background We have recently developed a non-invasive periodontal diagnostic tool that was validated in periodontitis patients without systemic disorders like coronary artery disease (CAD). The purpose of present study is to verify whether this optical instrument can also be used in periodontitis patients with CAD. Methods A total of 62 periodontitis patients with CAD were recruited along with a control group consisting of 59 age and gender matched periodontitis volunteers without systemic disorders. Using a portable optical near-infrared spectrometer, optical spectra were obtained, processed and evaluated from the two groups. A modified Beer-Lambert unmixing model that incorporates a nonparametric scattering loss function was used to determine the relative contribution of deoxygenated hemoglobin (Hb) and oxygenated hemoglobin (HbO2) to the overall spectrum. The balance between tissue oxygen delivery and utilization in periodontal tissues was then assessed. Results Tissue oxygen saturation was significantly decreased in the periodontitis sites (p < 0.01), compared to the healthy sites in those individuals with CAD. There was a trend towards increased concentration of Hb and decreased concentration of HbO2 from healthy to diseased sites, without statistical significance (p > 0.05). No statistical differences were found in tissue oxygen saturation between the CAD and control groups either in periodontal healthy or inflammatory sites. Conclusion This study supports the hypothesis that optical spectroscopy can determine the periodontal inflammation in patients with certain systemic disorders like CAD. And the overall periodontal oxygenation profiles in CAD patients resemble those in non-CAD individuals either in healthy or inflammatory sites.
dc.description.versionPeer Reviewed
dc.identifier.citationBMC Oral Health. 2014 Mar 25;14(1):25
dc.identifier.doihttp://dx.doi.org/10.1186/1472-6831-14-25
dc.identifier.urihttp://hdl.handle.net/1993/23541
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderChunyang Zhang et al.; licensee BioMed Central Ltd.
dc.titleAssessment of tissue oxygenation of periodontal inflammation in patients with coronary artery diseases using optical spectroscopy
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
1472-6831-14-25.xml
Size:
69.73 KB
Format:
Extensible Markup Language
Description:
Download
Thumbnail Image
Name:
1472-6831-14-25.pdf
Size:
1.26 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.17 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
University of Manitoba Scholarship
Rady Faculty of Health Sciences Scholarly Works