Localisation of equilibrative nucleoside transporter 3 (ENT3) in mouse brain

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dc.contributor.authorRoberts, Lauren Emilienne
dc.contributor.examiningcommitteeMiller, Donald (Pharmacology and Therapeutics) Triggs-Raine, Barbara (Biochemistry and Medical Genetics)en_US
dc.contributor.supervisorParkinson, Fiona E. (Pharmacology and Therapeutics)en_US
dc.date.accessioned2015-01-12T17:24:47Z
dc.date.available2015-01-12T17:24:47Z
dc.date.issued2015-01-12
dc.degree.disciplinePharmacology and Therapeuticsen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractAdenosine is an essential purine nucleoside of particular importance within heart and brain. The widespread and diverse actions of adenosine, driven by activation of cell surface receptors, include regulation of sleep/arousal and neuroprotective properties. The mechanisms involved in regulating adenosine concentrations remain poorly understood but are critical to signaling pathways as they determine the availability of adenosine at corresponding receptors within the extracellular space. The equilibrative nucleoside transporter (ENT) family, bi-directional, Na+-independent nucleoside transporters, are key components in both the release and uptake of adenosine. This study has been conducted to investigate ENT3, a novel member of the ENT family. Our work has demonstrated ENT3 to be expressed throughout brain, located in cortex, cerebellum, striatum and hippocampus, at similar levels. Neurons and astrocytes, but not microglia, showed intracellular ENT3 localisation. This was confirmed by differential centrifugation, of cortex and cerebellum, which suggests ENT3 to be found within the cytoplasm.en_US
dc.description.noteFebruary 2015en_US
dc.identifier.urihttp://hdl.handle.net/1993/30193
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectAdenosineen_US
dc.subjectCentral nervous system (CNS)en_US
dc.subjectEquilibrative nucleoside transporteren_US
dc.subjectEquilibrative nucleoside transporter 3en_US
dc.subjectENT3en_US
dc.subjectBrainen_US
dc.subjectLocalisationen_US
dc.subjectTransportersen_US
dc.subjectENTen_US
dc.titleLocalisation of equilibrative nucleoside transporter 3 (ENT3) in mouse brainen_US
dc.typemaster thesisen_US
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