The effect of galanin alone and combined with estrogen in a cuprizone-induced demyelination mouse model of multiple sclerosis

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dc.contributor.authorZhang, Lin
dc.contributor.examiningcommitteeParkinson, Fiona (Pharmacology and Therapeutics) VBergen, Hugo (Human Anatomy and Cell Science)en_US
dc.contributor.supervisorVrontakis, Maria (Human Anatomy and Cell Science) Kong, Jiming (Human Anatomy and Cell Science)en_US
dc.date.accessioned2011-08-09T17:47:15Z
dc.date.available2011-08-09T17:47:15Z
dc.date.issued2011-08-09
dc.degree.disciplineHuman Anatomy and Cell Scienceen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractMultiple Sclerosis (MS) is an autoimmune demyelination disease of the central nervous system (CNS). The traditional immunotherapies so far have not been able to stop the progression of the disease. Galanin (GAL) is an inducible neuropeptide. It has diverse regulatory effects in the nervous. The expression of galanin is induced by the administration of estrogen and is increased during pregnancy in rodents. In women with MS, pregnancy has a protective effect associated with significant remission of MS symptoms during the second and third trimester. In this study, using the cuprizone (CPZ) demyelination model of MS I demonstrated that GAL has a pronounced neuroprotective effect on demyelination and remyelination, with estrogen the protection was further enhanced. Moreover, I also found differential activation of GAL receptors in the demyelination and remyelination processes. These results suggest GAL alone or combined with estrogen might introduce next generation strategies for the treatment of MS.en_US
dc.description.noteOctober 2011en_US
dc.identifier.urihttp://hdl.handle.net/1993/4749
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectMultiple sclerosisen_US
dc.subjectgalaninen_US
dc.subjectestrogenen_US
dc.subjectcuprizoneen_US
dc.subjectdemyelinationen_US
dc.subjectremyelinationen_US
dc.titleThe effect of galanin alone and combined with estrogen in a cuprizone-induced demyelination mouse model of multiple sclerosisen_US
dc.typemaster thesisen_US
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