Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers

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dc.contributor.authorThakur, Ajit
dc.contributor.authorFitzpatrick, Scott
dc.contributor.authorZaman, Abeyat
dc.contributor.authorKugathasan, Kapilan
dc.contributor.authorMuirhead, Ben
dc.contributor.authorHortelano, Gonzalo
dc.contributor.authorSheardown, Heather
dc.date.accessioned2012-12-31T12:07:21Z
dc.date.available2012-12-31T12:07:21Z
dc.date.issued2012-06-11
dc.date.updated2012-12-31T12:07:21Z
dc.description.abstractAbstract Controlling gene expression via small interfering RNA (siRNA) has opened the doors to a plethora of therapeutic possibilities, with many currently in the pipelines of drug development for various ocular diseases. Despite the potential of siRNA technologies, barriers to intracellular delivery significantly limit their clinical efficacy. However, recent progress in the field of drug delivery strongly suggests that targeted manipulation of gene expression via siRNA delivered through nanocarriers can have an enormous impact on improving therapeutic outcomes for ophthalmic applications. Particularly, synthetic nanocarriers have demonstrated their suitability as a customizable multifunctional platform for the targeted intracellular delivery of siRNA and other hydrophilic and hydrophobic drugs in ocular applications. We predict that synthetic nanocarriers will simultaneously increase drug bioavailability, while reducing side effects and the need for repeated intraocular injections. This review will discuss the recent advances in ocular siRNA delivery via non-viral nanocarriers and the potential and limitations of various strategies for the development of a ‘universal’ siRNA delivery system for clinical applications.
dc.description.versionPeer Reviewed
dc.identifier.citationJournal of Biological Engineering. 2012 Jun 11;6(1):7
dc.identifier.doihttp://dx.doi.org/10.1186/1754-1611-6-7
dc.identifier.urihttp://hdl.handle.net/1993/14388
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderAjit Thakur et al.; licensee BioMed Central Ltd.
dc.titleStrategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
dc.typeJournal Article
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