c-Myc- driven nuclear repositioning of chromosome 11 in mouse plasmacytomas and its clinical significance
| dc.contributor.author | Sunpaweravong, Patrapim | |
| dc.contributor.examiningcommittee | Vrontakis, Maria (Human Anatomy and Cell Science) Hombach-Klonisch, Sabine (Human Anatomy and Cell Science) Simard, Louise (Biochemistry and Medical Genetics) | en_US |
| dc.contributor.supervisor | Mai, Sabine (Human Anatomy and Cell Science) | en_US |
| dc.date.accessioned | 2017-01-27T16:27:02Z | |
| dc.date.available | 2017-01-27T16:27:02Z | |
| dc.date.issued | 2016 | |
| dc.degree.discipline | Human Anatomy and Cell Science | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Overall, this study enhances our understanding of the role of c-Myc activation in chromosome 11 repositioning in mouse PreB v-abl/myc cells and a possible interaction between telomeres, TRF2, and lamin A/C underlying this phenomenon. Additionally, the importance of human 17q25.3 is confirmed as a potential region involved in NSCLC tumorigenesis. A utilizationof the 3D telomeric organization profiles is demonstrated a tendency to categorize NSCLC patients into different prognostic subgroups, underscoring a potential future value of its clinical application. | en_US |
| dc.description.note | February 2017 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/32080 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | c-Myc | en_US |
| dc.subject | Repositioning | en_US |
| dc.subject | Mouse chromosome 11 | en_US |
| dc.subject | Plasmacytomas | en_US |
| dc.subject | Non-small cell lung cancer | en_US |
| dc.subject | Three-dimensional | en_US |
| dc.subject | Telomeres | en_US |
| dc.subject | Nuclear matrix | en_US |
| dc.subject | TRF2 | en_US |
| dc.subject | Lamin A/C | en_US |
| dc.title | c-Myc- driven nuclear repositioning of chromosome 11 in mouse plasmacytomas and its clinical significance | en_US |
| dc.type | master thesis | en_US |