Variations in Adipokine Genes AdipoQ, Lep, and LepR Are Associated with Risk for Obesity-Related Metabolic Disease: The Modulatory Role of Gene-Nutrient Interactions

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dc.contributor.authorEnns, Jennifer Emily
dc.contributor.authorTaylor, Carla G.
dc.contributor.authorZahradka, Peter
dc.date.accessioned2015-05-14T16:42:18Z
dc.date.available2015-05-14T16:42:18Z
dc.date.issued2011-5-18
dc.date.updated2015-03-29T13:35:40Z
dc.description.abstractObesity rates are rapidly increasing worldwide and facilitate the development of many related disease states, such as cardiovascular disease, the metabolic syndrome, type 2 diabetes mellitus, and various types of cancer. Variation in metabolically important genes can have a great impact on a population's susceptibility to becoming obese and/or developing related complications. The adipokines adiponectin and leptin, as well as the leptin receptor, are major players in the regulation of body energy homeostasis and fat storage. This paper summarizes the findings of single nucleotide polymorphisms in these three genes and their effect on obesity and metabolic disease risk. Additionally, studies of gene-nutrient interactions involving adiponectin, leptin, and the leptin receptor are highlighted to emphasize the critical role of diet in susceptible populations.
dc.description.versionPeer Reviewed
dc.identifier.citationJennifer Emily Enns, Carla G. Taylor, and Peter Zahradka, “Variations in Adipokine Genes AdipoQ, Lep, and LepR Are Associated with Risk for Obesity-Related Metabolic Disease: The Modulatory Role of Gene-Nutrient Interactions,” Journal of Obesity, vol. 2011, Article ID 168659, 17 pages, 2011. doi:10.1155/2011/168659
dc.identifier.urihttp://dx.doi.org/10.1155/2011/168659
dc.identifier.urihttp://hdl.handle.net/1993/30511
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2011 Jennifer Emily Enns et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleVariations in Adipokine Genes AdipoQ, Lep, and LepR Are Associated with Risk for Obesity-Related Metabolic Disease: The Modulatory Role of Gene-Nutrient Interactions
dc.typeJournal Article
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